Synthesis of Related Substances of Posaconazole Intermediates
N'-[(2S,3S)-2-(benzoxy)pentane-3-yl]formylhydrazine oxalate(2)is the key inter-mediate for the preparation of posaconazole.In order to control the quality of posaconazole,three related substances of 2 were prepared:N'-[(2S,3R)-2-(benzyloxy)pentan-3-yl]formohydrazide oxalate(related substance A),N'-[(2R,3S)-2-(benzyloxy)pentan-3-yl]formohydrazide oxalate(related substance B),N'-[(2R,3R)-2-(Benzyloxy)pentan-3-yl]formohydrazide oxalate(relat-ed substance C).The structures of three related substances were confirmed by NMR,ESI-MS and infrared spectroscopy.
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