Factors influencing worsening renal function in elderly patients with acute heart failure
Objective:To investigate the relationship between renal function deterioration and brain natriuretic peptide(BNP)and blood lactic acid in elderly patients with acute heart failure(AHF).Methods:110 elderly patients with AHF treated in Anyang Third People's Hospital from November 2020 to December 2021 were selected as the study objects.According to whether worsening renal function(WRF)developed during hospitalization,the patients were divided into a WRF group(n=36)and a non-WRF group(n=74).General data of the two groups were collected,and the levels of BNP,blood lactic acid,uric acid,blood urea nitrogen(BUN),hemoglobin(Hb),blood creatinine,cystatin C(cystatin C),left ventricular end-diastolic diameter and left ventricular ejection frac-tion were detected in the two groups.Multivariate logistic regression was used to analyze the influencing factors of WRF in elderly pa-tients with AHF.Results:Univariate analysis showed that there were significant differences between the two groups in terms gender,hy-pertension complication,diabetes,dyspnea,lower limb edema,jugular filling＞10cm,moist rales ≥ 1/3 in lung fields,BNP,Cys-C,blood lactic acid,and HB(P＜0.05).Multivariate logistic regression analysis indicated that diabetes mellitus(P=0.010,OR=2.502),dyspnea(P=0.013,OR=1.177),lower limb edema(P=0.005,OR=1.723),jugular filling＞10cm(P=0.021,OR=4.513),moist rales≥1/3 in lung fields(P=0.011,OR=1.327),blood lactic acid(P=0.010,OR=2.517),BNP(P=0.024,OR=1.931)levels were independent influencing factors for WRF in elderly patients with AHF.Conclusion:The deterioration of renal func-tion in elderly patients with AHF is closely related to BNP and blood lactic acid level.Diabetes mellitus,kidney volume status,BNP and blood lactic acid level are the influencing factors for the occurrence of WRF in elderly patients with AHF.Relevant risk factors should be effectively controlled clinically and effective measures should be taken to reduce the risk of WRF occurrence in elderly pa-tients with AHF.
Acute heart failureDeterioration of renal functionBrain natriuretic peptideBlood lactic acid
万方数据
维普
