Application of coagulation function and fibrinolytic index detection in diagnosis of pregnancy induced hypertension syndrome
Objective:To explore the application value of coagulation function and fibrinolytic index detection in the diagnosis of pregnancy induced hypertension syndrome.Methods:78 patients with gestational hypertension syndrome admitted to our hospital were selected as an observation group,which was redivided into 3 subgroups:a gestational hypertension groups(32 cases),a mild pre-eclampsia group(24 cases),and a severe preeclampsia group(22 cases).Meanwhile,78 healthy pregnant women admitted during the same period were selected as a control group.Blood was collected to check the levels of prothrombin time(PT),thrombin time(TT),activated part prothrombin time(APTT),D-dimer(D-D),predicted fibrinolytic index(EPL),fibrinolytic index(LY30),and antithrombin Ⅲ(AT-Ⅲ),and compare the coagulation function and fibrinolytic index between the two groups.The coagulation function and fibrinolytic indicators of the three subgroups were also compared.Receiver operating characteristic(ROC)was drawn to analyze the clinical value of PT,TT,APTT,D-D,EPL,LY30,AT-Ⅲ and the joint detection in the diagnosis of pregnancy induced hypertension syndrome.Results:The results showed that the PT,TT,APTT and AT-Ⅲ in the observation group were(9.56±1.13)s,(12.41±1.15)s,(25.69±2.13)s,and(91.63±7.58)％,which were shorter or lower than the control group s(13.02±1.28)s,(16.18±1.25)s,(34.58±2.41)s,and(105.89±10.12)％,the differences being statistically significant(P＜0.05).The EPL,LY30,and D-D of the observation group were(2.98±0.42)％,(8.18±1.26)％,and(365.41±40.15)g/L,which were higher than those of the control group(1.84±0.25)％,(5.45±0.89)％,and(156.89±10.25)g/L,with statistical significance(P＜0.05).Pa-tients with severe preeclampsia had shorter PT,TT,and APTT compared to those with mild preeclampsia and gestational hypertension,while AT-Ⅲ levels were lower than those with mild preeclampsia and gestational hypertension,with statistically significant differences(P＜0.05).The EPL,LY30,and D-D levels in patients with severe preeclampsia were significantly higher than those in patients with mild preeclampsia and gestational hypertension(P＜0.05).ROC analysis showed that the area under the curve of PT,TT,APTT,D-D,EPL,LY30,AT-Ⅲ and joint detection for diagnosis of pregnancy induced hypertension syndrome was 0.767,0.739,0.776,0.778,0.759,0.723,0.756,0.927,respectively,joint detection being of the highest value.Conclusion:The combination of coagulation func-tion and fibrinolytic index detection can improve the diagnostic efficacy of pregnancy induced hypertension syndrome,reduce the occur-rence of missed diagnosis and misdiagnosis,and can be used for assessing the severity of the disease condition,which is worthy of widespread application.
Pregnancy induced hypertension syndromeCoagulation functionFibrinolytic indexDiagnostic value
万方数据
维普
