目的:探讨血清β2-微球蛋白(β2-MG)、内脏脂肪素(visfatin)水平变化与老年高血压患者血压变异性(BPV)的关联性。方法:选取某院2021年1月—2022年12月收治的120例老年高血压患者为研究组，同期120例血压正常体检老年人为对照组，根据24 h收缩压变异性(24 h SBPV)将研究组分为低BPV(35例，24 h SBPV＜15％)、中BPV(47例，24 h SBPV为15％～20％)、高BPV(38例，24 h SBPV＞20％)3个亚组。比较2组入院时血清β2-MG、visfatin水平、血压参数，分析入院时血清β2-MG、visfatin水平与血压参数的相关性，比较不同程度BPV患者入院时血清β2-MG、visfatin水平，分析入院时血清β2-MG、vis-fatin 联合检测对老年高血压患者BPV程度的诊断价值。结果:研究组β2-MG[(5。46±1。13)mg/mL]、visfatin[(9。75±2。08)μg/L]水平高于对照组[(1。37±0。42)mg/mL、(2。86±0。61)μg/L]，差异具有统计学意义(P＜0。05);研究组 24 h DBP、24 h SBP、24 h DBPV、24 h SBPV均高于对照组，差异具有统计学意义(P＜0。05);入院时血清β2-MG、visfatin水平与24 h DBP、24 h SBP、24 h DBPV、24 h SBPV 均呈正相关，差异具有统计学意义(rβ2-MG=0。516、0。622、0。439、0。725，rvisfatin=0。703、0。681、0。617、0。658)(P＜0。05);不同程度BPV患者入院时血清β2-MG、visfatin水平比较:高BPV＞中BPV＞低BPV，差异具有统计学意义(P＜0。05);入院时，血清β2-MG、visfatin联合鉴别诊断高BPV严重程度AUC为0。909，大于单独指标鉴别诊断，差异具有统计学意义(P＜0。05)。结论:β2-MG、visfatin水平变化与老年高血压患者血压变异性有密切关联，可作为临床诊断病情的重要参考依据。
Correlation of serum β2-MG and visfatin levels with blood pressure variability in elderly patients with hypertension
Objective:To investigate the relationship between serum β2-microglobulin(β2-MG)and visfatin levels and blood pres-sure variability(BPV)in elderly patients with hypertension.Methods:120 elderly patients with hypertension in our hospital from Janu-ary 2021 to December 2022 were selected as the observation group,and 120 elderly patients with normal blood pressure were selected as the control group.According to the 24h SBPV,the elderly patients with hypertension were further divided into three subgroups:low BPV(35 cases,24h SBPV＜15％),medium BPV(47 cases,24h SBPV 15％～20％),and high BPV(38 cases,24h SBPV＞20％).Serum β2-MG,visfatin levels and blood pressure parameters at admission were compared between the two groups.Correlation between β2-MG,visfatin levels and blood pressure parameters was analyzed.Comparison of serum β2-MG and visfatin levels in patients with different degrees of BPV at admission was conducted.The diagnostic value of combined detection of β2-MG and visfatin for the de-gree of BPV in elderly patients with hypertension was assessed.Results:The levels of β2-MG[(5.46±1.13)mg/mL]and visfatin[(9.75±2.08)μg/L]in the observation group were higher than those in the control group[(1.37±0.42)mg/mL][(2.86±0.61)μg/L](P＜0.05);the observation group's 24h DBP,24h SBP,24h DBPV,and 24h SBPV were higher than those in the control group(P＜0.05).At admission,the levels of serum β2-MG and visfatin were positively correlated with 24h DBP,24h SBP,24h DBPV,and 24h SBPV(rβ2-MG=0.516,0.622,0.439,0.725,rvisfatin=0.703,0.681,0.617,0.658,P＜0.05).The comparison of serum β2-MG and visfatin levels in patients with different degrees of BPV at admission showed that high BPV(7.91±2.26;15.49±3.08)was higher than medium BPV(5.33±1.12;9.26±2.33)and lower BPV(2.98±0.57;4.18±1.24),with statistically significant differences(P＜0.05).At admission,the AUC of serum β2-MG and visfatin for the combined diagnosis of the severity of high BPV was 0.909,which was greater than that of individual indicators,with statistically significant differences(P＜0.05).Conclusion:Serum β2-MG and visfatin levels are closely related to blood pressure variability in elderly patients with hypertension,which can be used as an important reference for clinical diagnosis.
万方数据
维普
