Relationships between hepatic pathological changes and clinical manifestations in HBeAg positive and negative patients infec-ted with hepatitis B virus
Objective:To investigate correlations between HBV-related hepatic pathological changes and clinical biomarkers in HBeAg positive and negative patients.Methods:A total of 103 HBV-infected patients were collected as research objects,and were clas-sified into HBeAg positive group(39 cases)and a HBeAg negative group(64 cases)according to serum HBeAg levels.The role of clinical parameters in predicting the degree of liver inflammation and fibrosis in HBeAg positive and negative patients were analyzed carefully,including the age,sex,HBV DNA,ALT,AST,ALB,CHE,TBIL,and DBIL.Results:Comparing with HBeAg positive patients,the average age of HBeAg negative patients was higher(42.88±9.40 years vs.38.31±11.02 years,P=0.027).The serum level of ALB in HBeAg negative patients was higher than that in HBeAg positive patients(45.23±5.08 g/L vs.42.22±5.28 g/L,P=0.005).The difference of serum level of CHE between the two groups was also statistically significant(8 782.91±2 625.38 U/L vs.7 199.67±2 146.57 U/L,P=0.002).HBeAg negative group had lower prevalence of moderate to severe liver inflammation than that in HBeAg positive group(29.69％vs.53.85％,P=0.015).As for HBeAg positive patients,the degree of liver inflammation was positively correlated with the serum level of ALT(r=0.514,P=0.001),negatively correlated with the serum level of ALB(r=-0.331,P=0.037)and CHE(r=-0.509,P=0.001).Also,the degree of liver fibrosis was negatively correlated with the serum level of ALB(r=-0.485,P=0.002)and CHE(r=-0.512,P=0.001).In HBeAg negative patients,the degree of liver inflamma-tion showed positive relevance with age(r=0.28,P=0.022)and negative relevance with serum level of CHE(r=-0.337,P=0.005).Multivariate logistic regression analysis revealed that lower serum level of CHE was related to higher risk of moderate to severe liver inflammation in HBeAg negative patients(P＜0.05,OR＜1).Receiver operating characteristic(ROC)analysis identified that ar-ea under the curve(AUC)of CHE in predicting the level of liver inflammation in HBeAg negative patients was 0.723(95％CI:0.586～0.860),with a sensitivity of 82.2％and a specificity of 57.9％.Conclusion:The serum level of CHE in HBeAg negative patients has predictive value for the degree of liver inflammation.
Hepatitis B virusHbeAgCholine esteraseLiver pathology changesClinical manifestations
万方数据
维普
