Correlation between Nrf2,Hcy,and CysC levels and cognitive impairment in elderly patients with sleep apnea syndrome
Objective:To explore the correlation between Nrf2,Hcy,and CysC levels and cognitive impairment in elderly patients with sleep apnea syndrome(SAS).Methods:286 patients with SAS in a hospital from June 2021 to June 2023 were selected as ob-jects.All the patients underwent polysomnography(PSG)monitoring.Based on apnea hypopnea index(AHI),they were divided into a mild group(n=113),a moderate group(n=95)and a severe group(n=78).The 3 groups were compared in terms of sleep respira-tory monitoring indicators[lowest oxygen saturation(LSpO2)in sleep-disordered breathing events,maximum apnea time(Tmax),time of oxygen saturation＜90(T90),sleep time]and their serum levels of Nrf2,Hcy,and CysC on admission.Correlation between all relative serum indicators and sleep respiratory monitoring indicators was analyzed.Scores of MMSE and MoCA of the 3 groups on ad-mission were compared and the correlation with sleep respiratory monitoring indicators and all relative serum indicators were assessed.Results:Tmax[(37.83±6.62)s],T90[(22.37±12.14)％],sleep time[(8.42±1.22)h],and serum Nrf2[(2.27±1.07)ng/mL],Hcy[(24.77±3.15)mmol/L],CysC[(0.93±0.17)mg/L]of the patients in the mild group on admission were all lower than those of the moderate group[(44.62±4.76)s,(28.44±16.22)％,(9.77±1.47)h,(2.66±1.44)ng/mL,(26.89±3.77)mmol/L,(1.02±0.31)mg/L],and were further lower than those of the severe group[(63.54±5.77)s,(36.38±11.47)％,(10.56±1.14)h,(3.05±1.67)ng/mL,(30.54±4.21)mmol/L,(1.17±0.22)mg/L],the differences being statistically signifi-cant(P＜0.05).LSpO2[(86.21±2.42)％],MMSE[(26.12±2.24)分],MoCA[(27.63±2.56)分]of the mild group were all higher than those of the moderate group[(81.87±2.77)％,(24.33±3.17),(27.12±3.12)],and were further higher than those of the severe group[(74.14±3.11)％,(22.57±2.55),(26.54±2.47)],the differences being statistically significant(P＜0.05).Serum Nrf2,Hcy,CysC were positively correlated with AHI,Tmax,T90,and sleep time and negatively correlated with LSpO2(P＜0.05).Levels of MMSE,MoCA were negative-ly correlated with Nrf2,Hcy,CysC and AHI,Tmax,T90,sleep time,and positively correlated with LSpO2(P＜0.05).Conclusion:Serum Nrf2,Hcy,CysC were closely correlated with patients'sleep respiration status and cognitive impairment,which may be regarded as an assisted indicator for the diagnosis of SAS and assessment of cognitive function.
万方数据
维普
