Correlation between serum levels of Netrin-1,FGF22,miR-221 and cognitive impairment in patients with depression
Objective:To analyze the correlation between serum levels of Netrin-1,FGF22,miR-221 and cognitive impairment in patients with depression.Methods:120 patients with depression admitted to a hospital from June 2021 to July 2023 were chosen as the study objects,and another 120 healthy adults over the same period as controls.MMSE was used to appraise the patients'cognitive func-tion and HAMD-24 was applied to judge the degree of the patients'depression.Serum levels of Netrin-1,FGF22,and miR-221 of the patients with different cognitive status in the two groups were compared.Serum indicators and MMSE scores of the patients with differ-ent degrees of depression were also compared and the correlation between them was observed.Diagnostic value of joint detection of Ne-trin-1,FGF22,and miR-221 on cognitive impairment of the patients with depression on admission was appraised with ROC.Results:Serum levels of Netrin-1 and FGF22[(274.56±14.56)pg/mL,(157.46±21.47)ng/mL]of the observation group were both lower than those of the control group[(437.93±13.71)pg/mL,(217.56±20.66)ng/mL],while serum level of miR-22(3.67±1.26)was higher than that of the control group(1.06±1.39),the differences being significant(P<0.05).Serum levels of Netrin-1 and FGF22 of the patients with cognitive impairment[(177.46±37.16)pg/mL,(131.71±21.47)ng/mL]were lower than those with nor-mal cognition[(330.78±36.44)pg/mL,(172.37±19.56)ng/mL],while serum level of miR-22(4.14±1.14)was higher than that of the patients with normal cognition(3.24±1.26)(P<0.05).Serum levels of Netrin-1 and FGF22 and MMSE scores in the pa-tients with mild depression were higher than those in patients with moderate or severe depression,while serum level of miR-221 were lower than those patients(P<0.05).Serum levels of Netrin-1 and FGF22 were positively correlated with MMSE scores(r =0.694,0.677,all P<0.001),while miR-221 was negatively correlated with MMSE scores(r =-0.715,P<0.001)(P<0.05).The AUC indicators used to diagnose cognitive impairment with serum levels of Netrin-1,FGF22 and miR-221were respectively 0.749,0.814,0.766,and AUC in the joint detection by the 3 indicators was 0.926.Conclusion:Serum levels of Netrin-1 and FGF22 remarkably in-crease in depression patients with cognitive impairment,while serum level of miR-221 remarkably decreases,which were all closely correlated with cognitive impairment.The joint detection by the 3 indicators is of high value for the diagnosis of cognitive impairment in patients with depression.
万方数据
维普
