Predictive value of joint detection of serum β2-MG,Cys-C,and DKK1 in prognosis of patients with multiple myeloma
Objective:To analyze the expression level of β2-microglobulin(β2-MG),Cystatin C(Cys-C),and Dickkopf-1(DKK1)and its predictive value in prognosis of patients with multiple myeloma.Methods:101 patients with multiple myeloma admit-ted to Jinshui General Hospital of Zhengzhou from June 2019 to June 2023 were included in this study as an observation group,and an-other 76 healthy adults at the same period were chosen as a control group.Serum levels of β2-MG,Cys-C,and DKK1 of the 2 groups on admission were compared.Correlation of serum levels of β2-MG,Cys-C,and DKK1 with Durie Salmon(D-S)staging and ISS stag-ing was observed and predictive value in prognosis of patients with multiple myeloma was appraised.Results:On admission,the serum levels of β2-MG,Cys-C,and DKK1 of the observation group were respectively(8.31±0.81)mg/L,(1.71±0.31)mg/L and(8.61±1.86)mg/L,higher than those of the control group's(1.53±0.57)mg/L,(0.72±0.17)mg/L and(2.76±1.41)mg/L(P<0.05).In stage III of D-S staging,serum levels of β2-MG,Cys-C,and DKK1 of the patients with multiple myeloma were(8.78±1.88)mg/L,(1.92±0.57)mg/L and(9.13±1.77)mg/L respectively,higher than those of stages I-II patients'(7.56±1.57)mg/L,(1.37±0.36)mg/L and(7.78±1.59)mg/L(P<0.05).Serum levels of β2-MG,Cys-C,and DKK1 were positively cor-related with D-S staging and ISS staging(P<0.001).After3 months'treatment,serum levels of β2-MG,Cys-C,and DKK1 in the ineffective group were higher than those in the effective group(P<0.05).The AUC,sensitivily and specificity of joint detection of se-rum levels of β2-MG,Cys-C,and DKK1 in prediction of the prognosis of the patients with multiple myeloma were 0.822,83.91%and 92.86%respectively,higher than the separate detection of the three(P<0.05).Conclusion:Serum β2-MG,Cys-C,and DKK1 in patients with multiple myeloma are at a relatively high level.Joint detection of the three possesses good predictive value in the prognosis of the patients,which can be taken as serological markers in the judgement of therapeutic effect and prognosis.
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