Predictive value of joint detection of serum RDW and NT-proBNP on MACE in senile patients with acute heart failure
Objective:To analyze the correlation of red cell distribution width(RDW)and level of N terminal pro B type natriuretic peptide(NT-proBNP)with cardiac functional grading in patients with acute heart failure(AHF),and to explore the predictive value of joint detection of the two on major adverse cardiovascular events(MACE)in AHF patients.Methods:136 cases of AHF patients admit-ted to a hospital from February 2018 to September 2020 were selected as AHF group,and another 90 patients with chronic heart failure(CHF)were chosen as CHF group.At the same time,100 healthy adults were recruited as healthy group.Levels of NT-proBNP and RDW of the 3 groups were compared with each other.The correlation of NT-proBNP and RDW levels with cardiac functional grading in patients with AHF was analyzed.After one year's follow-up,based on the occurrence of MACE,the predictive value of joint detection of RDW and NT-proBNP on MACE in AHF patients was appraised.Results:Levels of NT-proBNP and RDW of the AHF group[(16.79±1.82)%,(6086.22±973.74)pg/mL]were higher than those of the CHF group[(14.86±1.32)%,(3168.57±875.69)pg/mL]and the healthy group[(12.81±0.73)%,(128.96±33.64)pg/mL](P<0.05).Serum RDW of the grade II,grade III and grade IV AHF patients were(14.67±0.56)%,(17.62±0.74)%,and(19.27±0.46)%,respectively,while serum NT-proBNP in those patients were respectively(5715.64±784.31)pg/mL,(6 234.45±850.53)pg/mL and(6 512.39±913.03)pg/mL.With the increase of cardiac functional grading,levels of RDW and NT-proBNP went up,the differences being significant(P<0.05).The cardiac functional grading was positively correlated with serum levels of RDW(r =0.607)and NT-proBNP(r =0.614)(P<0.05).Serum levels of RDW and NT-proBNP in AHF patients with MACE[(18.46±1.63)%,(6481.70±754.38)pg/mL]were higher than those without MACE[(16.47±1.42)%,(6009.90±669.75)pg/mL](P<0.05).The AUC,sensitivity,and specificity in joint detection of serum levels of RDW and NT-proBNP in AHF patients with MACE were respectively 0.944,90.91%,and 88.60%,higher than the results of separate detection(P<0.001).Conclusion:Serum levels of RDW and NT-proBNP in senile AHF patients are generally high.Changes of the levels are positively corre-lated the cardiac functional grading of the patients.Joint detection of the two is of high value for the prediction of the occurrence of MACE in AHF patients.
万方数据
维普
