Correlation analysis of serum LDH,ApoA1,TSGF levels and clinicopathological features in patients with colorectal cancer and value of combined diagnosis
Objective:To investigate the correlation of levels of lactate dehydrogenase(LDH),apolipoprotein A1(ApoA1)and tumor specific growth factor(TSGF)with clinicopathological features of colorectal cancer patients,and to analyze its diagnostic value in colorectal cancer.Methods:A total of 105 patients with colorectal cancer admitted to a hospital from January 2021 to January 2023 were selected as a colorectal cancer group,56 patients with colorectal adenoma during the same period were chosen as a colorectal ade-noma group,and 35 healthy volunteers were recruited as a control group.Serum levels of LDH,ApoA1 and TSGF were compared a-mong the groups.Changes of serum LDH,ApoA1 and TSGF in colorectal cancer patients with different clinicopathological features were observed,and their correlation with the clinicopathological features was analyzed.Receiver operating characteristic curve(ROC)was used to analyze the diagnostic efficacy of serum LDH,ApoA1 and TSGF in colorectal cancer.Results:The levels of serum LDH and TSGF in the colorectal cancer group were(302.16±99.52)U/L and(68.52±21.84)U/mL,respectively,which were higher than those in the colorectal adenoma group[(267.49±82.61)U/L and(57.49±16.16)U/mL]and the control group[(201.98±66.36)U/L and(43.28±14.18)U/mL].The level of serum ApoA1[(1.33±0.41)g/mL]was lower than that in the colorectal adenoma group[(1.58±0.51)g/mL]and the control group[(1.80±0.58)g/mL],the differences being statistically significant(P＜0.05).With the increase of TNM staging,lymph node metastasis,and serosal invasion,the levels of serum LDH and TSGF showed an upward trend,while the level of ApoA1 a downward trend.With the increase of differentiation degree,the levels of serum LDH and TSGF presented a downward trend,while the level of ApoA1 an upward trend,with significant differences(P＜0.05).Serum LDH,TSGF were positively correlated with TNM staging,lymph node metastasis,and serosal invasion(rLDH=0.526,0.632,0.485,P＜0.05;rTSGF=0.574,0.419,0.503,P＜0.05),and negatively correlated with differentiation degree(rLDH=-0.412,P＜0.05;rTSGF=-0.567,P＜0.05).ApoA1 was negatively correlated with TNM staging,lymph node metastasis,and serosal invasion(r=-0.528,-0.557,-0.601,P＜0.05),but positively correlated with differentiation degree(r=0.496,P＜0.05).The AUCs of serum LDH,ApoA1,TSGF,and combined detection for the diagnosis of colorectal cancer were 0.835,0.854,0.776,and 0.901 respectively,and the AUC of combined detection was greater than that of in-dividual indicators(P＜0.05).Conclusion:Patients with colorectal cancer have high expression of serum LDH and TSGF and low ex-pression of ApoA1.Serum LDH and TSGF are positively correlated with TNM staging,lymph node metastasis,and serosal invasion,and negatively correlated with differentiation degree.ApoA1 is the opposite.Combined detection of their levels has certain diagnostic value for colorectal cancer.
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