Exploration of relationship between HSP70 expression in thyroid cancer tissue and clinical pathological characteristics and postoperative recurrence
Objective:To investigate the relationship between the expression of heat shock protein 70(HSP70)in thyroid cancer tissue and clinical pathological characteristics and postoperative recurrence.Methods:A retrospective analysis was conducted on the clinical data of 165 patients with thyroid cancer who underwent surgical treatment in a hospital from June 2018 to December 2019.The expressions of HSP70 in thyroid cancer tissue and adjacent normal tissues were detected using immunohistochemical methods.The ex-pressions of HSP70 in thyroid cancer tissues with different clinical pathological characteristics were compared.The influencing factors of postoperative recurrence in thyroid cancer were analyzed using univariate and multivariate Logistic regression analysis.Results:The ex-pression of HSP70 in thyroid cancer tissue(0.87±0.23)was higher than that in adjacent normal tissue(0.41±0.07),and the difference was statistically significant(P<0.001).The expressions of HSP70 in thyroid cancer tissues of patients with maximum tumor diameter>4cm,non-differentiated,TNM stages Ⅲ～Ⅳ,and lymph node metastasis(0.95±0.27,1.39±0.32,1.02±0.28,0.99±0.26)were higher than those of patients with maximum tumor diameter≤4cm,differentiated,TNM stages Ⅰ～Ⅱ,and no lymph node metastasis(0.83±0.23,0.72±0.19,0.69±0.15,0.75±0.21),the differences being statistically significant(P<0.05).The 3-year recurrence rate of thyroid cancer patients after surgery was23.64％(39/165).The results of multivariate Logistic regression a-nalysis showed that maximum tumor diameter>4cm(95％CI:1.311～5.130,P=0.006),non-differentiated(95％CI:1.895～7.500,P<0.001),TNM stage Ⅲ～Ⅳ(95％CI:1.567～6.105,P=0.001),lymph node metastasis(95％CI:1.205～4.226,P=0.013),and elevated HSP70 expression(95％CI:1.568～7.976,P=0.002)in thyroid cancer tissue were independent risk factors for postoperative recurrence of thyroid cancer(P<0.05).Conclusion:HSP70 is highly expressed in thyroid cancer tissue,which is related to tumor size,pathological type,TNM staging,lymph node metastasis and postoperative recurrence,and high expression of HSP70 in thyroid cancer tissue,maximum tumor diameter>4cm,non-differentiated,TNM stage Ⅲ～Ⅳ,and lymph node metastasis are inde-pendent risk factors for postoperative recurrence of thyroid cancer.
Thyroid cancerHeat shock protein 70Clinical pathological characteristicsPostoperative recurrence
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