Level changes of MYO,cTnI and CK-MB in patients with chronic heart failure and their clinical significance
Objective:To investigate the correlation between serum myoglobin(MYO),troponin I(cTnI)and creatine kinase isoenzyme(CK-MB)levels and cardiac function in patients with chronic heart failure(CHF),and to analyze their predictive value for therapeutic effect.Methods:92 CHF patients admitted to a hospital from July 2021 to July 2023 were selected as a study group,and another 92 healthy volunteers in the same period were recruited as a control group.The correlation between serum MYO,cTnI,CK-MB levels and cardiac function grading in the two groups were compared.Serum MYO,cTnI,and CK-MB levels of those with different effi-cacies were compared and analyzed for their correlation with the efficacy of the treatment,ROC was plotted and their predictive value for the efficacy was assessed.Results:The levels of serum MYO,cTnI,and CK-MB in the study group were higher than those in the con-trol group(P＜0.05).As the NYHA classification of cardiac function increased,the levels of serum MYO,cTnI,and CK-MB showed an upward trend(P＜0.05).The levels of serum MYO,cTnI,and CK-MB were positively correlated with the NYHA classification of cardiac function(r=0.448,0.462,0.537,all P＜0.05).The levels of serum MYO,cTnI,and CK-MB in the ineffective group were higher than those in the effective group(P＜0.05).The levels of serum MYO,cTnI,and CK-MB after7 days of treatment were inde-pendent factors affecting the efficacy(P＜0.05).The AUCs of serum MYO,cTnI,CK-MB alone and in combination for predicting the efficacy were 0.801,0.769,0.829,and 0.963,respectively,and the AUC of combined prediction was greater than that of single in-dex prediction(P＜0.05).Conclusion:The levels of serum MYO,cTnI,and CK-MB in patients with CHF are elevated and positively correlated with the classification of cardiac function.Combined detection of their levels has certain predictive value for therapeutic effi-cacy and may serve as a potential indicator for predicting therapeutic efficacy.
Chronic heart failureMyoglobinTroponin ⅠCreatine kinase isoenzymePredictive value
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