Correlation between placental growth factor and uterine artery hemodynamic parameters and its predictive efficacy in pre-eclampsia
Objective:To analyze the correlation between placental growth factor(PLGF)and uterine artery hemodynamic parame-ters and its predictive efficacy for preeclampsia.Methods:This article is a retrospective study,with cases included from January 2021 to May 2023.122 patients with hypertensive disorders of pregnancy(HDP)were divided into a high-risk group(32 cases),a medium risk group(45 cases),and a low risk group(45 cases)based on the severity of their condition.The differences in PLGF and uterine artery hemodynamic parameters among the three groups of patients were compared.The Pearson correlation coefficient was used to test the correlation between PLGF and uterine hemodynamic parameters.Statistics were conducted on the occurrence of preeclampsia in the 122 HDP patients and they were divided into a preeclampsia group and a non-preeclampsia group.The differences in PLGF and uterine hemodynamic parameters between the two groups were compared.The predictive efficacy of PLGF on preeclampsia was verified through ROC and AUC observation.Results:After testing,the PLGF of the high-risk group was(40.24±10.31)pg/ml,lower than that of the medium risk group(48.24±10.36)pg/ml and the low risk group(55.62±15.45)pg/ml.The PI,RI,and S/D of uterine arteries in the high-risk group were(1.66±0.23),(0.77±0.23),and(3.39±0.27),respectively,which were higher than those in the medium risk group[(1.08±0.21),(0.56±0.14),(2.92±0.36)],and the low risk group[(0.84±0.16),(0.39±0.15),and(2.21±0.36)](P＜0.05).The correlation coefficient test indicated that PLGF was negatively correlated with uterine artery hemodynamic parameters such as PI,RI,and S/D.Among the 122 HDP patients,41 developed preeclampsia,with the incidence of 33.61%.The PLGF of the preeclampsia group was(60.41±10.27)pg/ml,lower than that of the non preeclampsia group(55.16±10.71)pg/ml;PI,RI,and S/D were(2.05±0.36),(0.83±0.21),and(4.12±1.25),respectively,higher than those in the non preeclampsia group[(1.71±0.43),(0.71±0.22),and(3.44±0.47)](P＜0.05).The predic-tive sensitivity and specificity of PLGF for preeclampsia were 80.23%and79.36%,respectively,with a cutoff value of 57.79ng/ml and AUC=0.856(95%CI:0.802～0.911).Conclusion:PLGF will continuously decrease with the increase of PI,RI,and S/D in HDP patients,and dynamic monitoring of PLGF lev-els can achieve early prediction of preeclampsia.
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