Correlation analysis between serum WBC,IL-6,D-D levels and clinical prognosis in children with drug-resistant Mycoplasma pneumoniae infection
Objective:To investigate the correlation between white blood cell(WBC),interleukin-6(IL-6),and D-dimer(D-D)levels and clinical prognosis in children with drug-resistant Mycoplasma pneumoniae(MP).Methods:150 MP-infected children who visited a hospital from August 2021 to August 2023 were selected,and throat swabs were collected for MP culture and drug sensitivity testing.The children were divided into a drug-resistant group(n=64)and a non-drug-resistant group(n=86)based on MP resist-ance,and serum WBC,IL-6,and D-D levels were compared between the two groups.The children in the drug-resistant group were re-divided into two groups according to their prognosis,and the serum WBC,IL-6,D-D levels and paediatric critical illness score(PCIS)were compared between the two groups at the time of admission and 3 days after the treatment.The correlation between levels of serum WBC,IL-6,D-D and PCIS scores was analyzed by Pearson's analysis.ROC curves were plotted to analyze the influence of the serum WBC,IL-6 and D-D levels on the prognosis of the patients with drug-resistant MP infection.Results:The WBC,IL-6 and D-D levels of the children in the drug-resistant group were higher than those in the non-drug-resistant group(P＜0.05).At admission,the levels of WBC,IL-6,and D-D of the children in the good prognosis group were lower than those in the poor prognosis group,and their PCIS scores were higher than those in the poor prognosis group(P＜0.05).3 days after the treatment,the levels of WBC,IL-6,and D-D of both groups of children decreased compared with those at admission,while the PCIS scores increased(P＜0.05).In addition,the WBC,IL-6,and D-D levels of children in the good prognosis group were lower than those in the poor prognosis group,and their PCIS scores were higher than those in the poor prognosis group(P＜0.05).Pearson correlation analysis showed that the PCIS score was nega-tively correlated with serum WBC,IL-6,and D-D levels(r=-0.456,-0.511,-0.468,all P＜0.001).The AUCs of WBC,IL-6 and D-D for diagnosing poor prognosis of children with drug-resistant MP infection were 0.841,0.732 and 0.825,and the AUC of the combination of the three diagnoses was0.935,with a sensitivity and specificity of 93.70%and85.40%,respectively.Conclusion:WBC,IL-6 and D-D levels show high expression in children with drug-resistant MP infection,and there is an association with poor prog-nosis,and the combined detection of the three could help to predict the prognosis of children with drug-resistant MP infection and guide the clinical diagnosis and treatment.
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