Correlation between blood pressure levels and post stroke cognitive impairment in patients with acute ischemic stroke receiv-ing thrombolytic therapy
Objective:To investigate the correlation between blood pressure levels and post stroke cognitive impairment(PSCI)in patients treated by thrombolytic therapy for acute ischemic stroke,and to provide further intervention guidance for the prevention and treatment of PSCI.Methods:A total of 136 patients with acute ischemic stroke who received thrombolytic therapy in The First Affiliated Hospital of Bengbu Medical University from January 2023 to December 2023 were selected in this study.The blood pressure levels were collected,and the Mini-Mental State Examination Scale(MMSE)and Montreal Cognitive Assessment(MoCA)were used to assess cognitive function.According to the assessment,the patients were divided into a PSCI group and a cognitive normal group.General da-ta and blood pressure levels of the two groups were compared.The correlation between blood pressure level and cognitive function was analyzed by the Spearman correlation.The logistic regression was used to analyze the influencing factors of PSCI in patients with acute ischemic stroke who received thrombolytic therapy.Results:Age,hypertension,triglyceride(TG),total cholesterol(TC),systolic blood pressure(SBP),and pulse pressure(PP)in the PSCI group were higher than those in the cognitive normal group.The total scores of MMSE and MoCA in the PSCI group were(19.10±2.88)and(18.89±3.01),lower than(23.34±2.92)and(21.03±3.94)in the cognitive normal group,and the differences were statistically significant(P<0.05).The Spearman analysis results showed that SBP and PP levels were negatively correlated with the total score of MMSE(r=-0.509,-0.658)and MoCA(r=-0.318,-0.446,all P<0.001).Logistic regression analysis indicated that the increase of PP was a risk factor for PSCI in patients with acute is-chemic stroke who received thrombolytic therapy(P<0.001).ROC curve analysis results showed that PP predicted the AUC of PSCI in patients with acute ischemic stroke was 0.856,sensitivity and specificity were 75.02%and 90.61%,respectively.Conclusion:The blood pressure level is positively correlated with PSCI in patients treated by thrombolytic therapy for acute ischemic stroke,and PP has a certain value in predicting the occurrence of PSCI.Reducing pulse pressure may effectively prevent the occurrence of PSCI.
万方数据
维普
