摘要
婴儿癫痫性痉挛综合征(IESS)是最近几年提出的一个新概念,是一种独特的、具有年龄特异性的难治性癫痫综合征.近年来,随着分子生物学、神经免疫学的发展以及抗癫痫药物抗痫机制的深入研究,在IESS的定义及治疗方面,取得了一些成果.目前传统抗癫痫药物的使用日趋减少.新型抗癫痫药物有增加趋势.本文查阅近几年来相关文献,从IESS的发病机制、流行病学、病因、诊断方法、治疗手段、治疗药物、临床进展,以及有效性和安全性等方面进行综述,以介绍IESS的研究现状和已有成果.
Abstract
Infantile epileptic spasm syndrome(IESS)is a new concept proposed recently.IESS is a unique and age-specific refractory epilepsy syndrome.The recent advances in molecular biology,neuroimmunol-ogy and the in-depth study of anti-epileptic mechanism in antiepileptic drugs have led to the achievements in the definition and treatment of infantile epileptic spasm.At present,the use of traditional antiepileptic drugs is de-creasing,while the use of new antiepileptic drugs is increasing.In this paper,based on the relevant literature in recent years,the authors discuss the pathogenesis,epidemiology,etiology,diagnosis,treatment,therapeutic drugs,clinical progress,efficacy,and safety of infantile epileptic spasm,hoping to introduce the latest status in research and achievements of IESS.
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