参数σ2(k·ECx)与多元混合物联合作用的关系研究
RELATIONSHIP BETWEEN PARAMETER σ2(k·ECx) AND INTERACTION OF MULTI-COMPONENT MIXTURES
王娜 1杨鑫悦 1蔡文涛 2孙嘉靖 1马晓妍 3张豫姣1
作者信息
- 1. 西安科技大学建筑与土木工程学院,西安 710054
- 2. 东营市生态环境局广饶县分局,山东东营 257000
- 3. 西安建筑科技大学环境与市政工程学院,西安 710055
- 折叠
摘要
表征多元混合物各组分浓度效应曲线(CRC)形态差异的参数σ2(k·ECx)可以预测多元混合物的联合毒性,进一步探索σ2(k·ECx)与多元混合物联合作用强度和方式的关系.选取11种环境污染物,按照物质CRC的参数k·ECx的数值分为D组(相异体系)和S组(相似体系),设计18组多元混合物,借助独立作用模型(IA)和效应残差比(ERRx)模型评价混合物的联合作用.结果表明:D组混合体系易发生联合作用方式的转变;S组混合体系联合作用方式保持不变.D组中(σ2(k·ECx))较大的混合物不易发生联合作用方式的转变.D组混合物整体联合作用强度大于S组,各混合体系内联合作用强度与(σ2(k·ECx))正相关.该研究揭示了参数σ2(k·ECx)与多元混合物联合作用的关系,实现了从几何角度对多元混合物联合作用的预判,为环境风险评价提供一定的理论支持.
Abstract
Previous studies have found that the parameter k·ECx can characterize the shape of the concentration-reaction curves(CRCs),and its derived parameter σ2(k·ECx)(the variance of k·ECx for each component)can predict the combined toxicity of multi-component mixtures.This study further explored the relationship between σ2(k·ECx)and the strength and mode of joint action.Eleven environmental pollutants were divided into group D(different system)and group S(similar system)according to the value of parameter k·ECx.A total of 18 mixtures(11 in group D,and 7 in group S)were designed.The joint action of mixtures was evaluated by independent action model(IA)and effect residual ratio(ERRx)model.The mixed systems with different parameters k·ECx(group D in this paper)were prone to change the mode of joint action.The mixed systems with similar k·ECx of each component(group S in this paper)kept the mode of interaction unchanged.In the group D,the mode of interaction of mixtures with a larger(σ2(k·ECx))was not easy to change.The strength of the joint action of group D was greater than that of group S overall.The strength of the interaction in every mixed system was positively correlated with the(σ2(k·ECx)).This study revealed the relationship between the σ2(k·ECx)and the joint action of multiple mixtures,and achieved the prejudgement of the joint action of multiple mixtures from a geometric perspective,which can provide certain theoretical support for the environmental risk assessment.
关键词
σ2(k·ECx)/IA/费氏弧菌/急性毒性/联合作用Key words
σ2(k·ECx)/IA/aliivibrio fischeri/acute toxicity/joint action引用本文复制引用
出版年
2024
NETL
NSTL
万方数据