RELATIONSHIP BETWEEN PARAMETER σ2(k·ECx) AND INTERACTION OF MULTI-COMPONENT MIXTURES
Previous studies have found that the parameter k·ECx can characterize the shape of the concentration-reaction curves(CRCs),and its derived parameter σ2(k·ECx)(the variance of k·ECx for each component)can predict the combined toxicity of multi-component mixtures.This study further explored the relationship between σ2(k·ECx)and the strength and mode of joint action.Eleven environmental pollutants were divided into group D(different system)and group S(similar system)according to the value of parameter k·ECx.A total of 18 mixtures(11 in group D,and 7 in group S)were designed.The joint action of mixtures was evaluated by independent action model(IA)and effect residual ratio(ERRx)model.The mixed systems with different parameters k·ECx(group D in this paper)were prone to change the mode of joint action.The mixed systems with similar k·ECx of each component(group S in this paper)kept the mode of interaction unchanged.In the group D,the mode of interaction of mixtures with a larger(σ2(k·ECx))was not easy to change.The strength of the joint action of group D was greater than that of group S overall.The strength of the interaction in every mixed system was positively correlated with the(σ2(k·ECx)).This study revealed the relationship between the σ2(k·ECx)and the joint action of multiple mixtures,and achieved the prejudgement of the joint action of multiple mixtures from a geometric perspective,which can provide certain theoretical support for the environmental risk assessment.
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