Toxic effects of waste salts derived from pyridine and nitrile-containing pharmaceutical intermediates on marine medaka(Oryzias melastigma)embryos
Industrial waste salt refers to the crystalline salt by-product produced during chemical production process.The manufacturing of fine chemicals,such as pesticides and pharmaceuticals,often generates a substantial amount of waste salt.The"National Hazardous Waste List"explicitly categorizes waste salt produced during the production of various chemical pharmaceuticals and pesticides as hazardous waste.However,high treatment expenses and limited disposal capacity hinder the healthy development of industries.The"Hazardous Waste Environmental Management Guide-Chemical Waste Salt"delineates the requirements for non-hazardous disposal of industrial waste salts,yet experimental research in this field is currently scarce.Marine medaka(Oryzias melastigma)exhibits similar research advantages to zebrafish and is acknowledged by the International Life Sciences Institute(ILSI)and the Health and Environmental Sciences Institute(HESI)as a valuable tool for marine ecotoxicology studies.This study assessed the acute and developmental toxicity,antioxidant and immune system effects of waste salts containing pyridine and nitrile pharmaceutical intermediates,as well as laboratory-treated impurity salt on marine medaka embryos.The results demonstrated that exposure to waste salt significantly affected the survival and development of marine medaka embryos and caused considerable system damage,while the treated impurity salt exhibited little effect.This study provides theoretical support for the non-hazardous disposal of waste salts and also provides guidance for future experimental design.
industrial waste saltmarine medaka(Oryzias melastigma)acute toxicitydevelopmental toxicityantioxidant system
万方数据
维普
