Risk assessment of dietary cadmium exposure on human health in northern China based on PBTK model
Cadmium(Cd)is a toxic heavy metal that poses a threat to human health through food chain contamination.Physiologically Based Toxicokinetic(PBTK)modeling is a valuable tool to quantify human exposure to environmental elements.Based on PBTK modeling,combined with extensive regional survey data,the potential urinary Cd(U-Cd)concentrations due to the consumption of Cd-contaminated food by the inhabitants of a major wheat-producing area in northern China were predicted.Results showed that 57.8％of the wheat grain samples exceeded the national food safety threshold value for Cd(0.1 mg·kg-1).Approximately 44.8％of residents had Cd intake concentrations surpassing the safe limit recommended by Joint FAO/WHO Expert Committee on Food Additives(JECFA)(0.8 μg·(kg·d-1)),while a significant 70.8％surpassed the European Food Safety Authority(EFSA)recommended intake value(0.36 μg·(kg·d-1))for Cd intake.PBTK modeling showed an increasing trend of U-Cd concentrations with age among the population.The U-Cd concentrations for 70-year-old females and males reached 1.60 µg·g-1 creatinine and 0.80 μg·g-1 creatinine,respectively.The U-Cd concentration for 70-year-old females was twice that of males and exceeded the EFSA recommended safety limit value(1 μg·g-1 creatinine)for U-Cd concentration.The application of the PBTK modeling for forecasting U-Cd accumulation across varied exposure groups is crucial in formulating effective regional measures to mitigate Cd contamination,thereby offering a scientific foundation for food safety risk assessment.
国家科技期刊平台
NSTL
万方数据
