Effect of coenzyme Q10 combined with soybean phospholipid on lipid-lowering in hyperlipidemia model rats
Objective Sprague-Dawley(SD)rat model of hyperlipidemia was established by high fat diet,and the effect of coenzyme Q10 combined with soybean phospholipid on the blood lipid level of rats was studied.Methods A total of 50 SPF grade male SD rats were randomly divided into 2 groups according to body weight,10 rats were given maintenance diet as blank control group and 40 rats were given high-fat model diet as model group.According to the level of serum total cholesterol(TC),the model group was randomly divided into 4 g/L coenzyme Q10+46 g/L soybean phospholipid group,8 g/L coenzyme Q10+92 g/L soybean phospholipid group,16 g/L coenzyme Q10+184 g/L soybean phospholipid group and model control group,with 10 rats in each group and the gavage volume was 5 ml/kg for 4 weeks.The model control group and the blank control group were given the same amount of corn oil.The blood of rat was collected from the venous plexus of inner canthus without fasting.Serum TC,TG,HDL-C,LDL-C levels were measured by automatic biochemical analyzer.Results After 4 weeks of oral administration by gavage of coenzyme Q10 combined with soybean phospholipid,the serum TC level of 8 g/L coenzyme Q10+92 g/L soybean phospholipid group was lower than that of model control group,and the difference was statistically significant(P＜0.05).There were no significant difference in TG and HDL-C and LDL-C levels between 4 g/L coenzyme Q10+46 g/L soybean phospholipid group,8 g/L coenzyme Q10+92 g/L soybean phospholipid group,16 g/L coenzyme Q10+184 g/L soybean phospholipid group and the model control group(P＞0.05).Conclusion Coenzyme Q10 combined with soybean phospholipid have the function of helping to maintain healthy blood cholesterol levels in rats.
万方数据
维普
