Association between maternal perfluoroalkyl and polyfluoroalkyl substances exposure during early pregnancy and dyslipidemia in offspring aged 5-6 years
Association between maternal perfluoroalkyl and polyfluoroalkyl substances exposure during early pregnancy and dyslipidemia in offspring aged 5-6 years
Objective To understand the relationship between blood perfluoroalkyl and polyfluoroalkyl substances(PFASs)levels of pregnant women during the first-trimester and dyslipidemia risk in offspring aged 5-6 years in Tianjin,and to provide reference for the formulation of pregnant health care and environmental health policies.Methods Collected and detected the levels of 35 PFASs in the serum of pregnant women during the first-trimester.A total of 151 pregnant women and their offspring were recalled when offspring were 5-6 years old.All children were tested for fasting total cholesterol(TC)and triglyceride(TG).Logistic regression model was used to analyze the relationship between PFASs levels in early pregnancy and dyslipidemia risk in offspring aged 5-6 years.Results Among 35 PFASs,the detection rate of 16 PFASs exceeded 60％.We detected 20 children with dyslipidemia.The results of multivariable Logistic regression showed that among 16 PFASs with a detection rate of more than 60％,PFNA(OR=4.63,95％CI:1.35-15.84),PFUdA(OR=4.71,95％CI:1.06-21.02),PFDA(OR=4.83,95％CI:1.34-17.44),and PFTrDA(OR=27.90,95％CI:1.31-594.80)levels during the first-trimester were positively correlated with dyslipidemia risk in offspring aged 5-6 years(P＜0.05).After grouping each above four PFASs levels into tertiles,the high concentration group showed an increased risk of dyslipidemia in children compared with the low concentration group(P＜0.05).Conclusion Prenatal exposure to PFASs increased the risk of dyslipidemia in offspring aged 5-6 years.
关键词
孕早期/全氟及多氟化合物/孕妇/子代/学龄前儿童/血脂
Key words
Early pregnancy/Perfluoroalkyl and polyfluoroalkyl substances/Pregnant woman/Offspring/Preschool children/Blood lipid
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