Rapid determination of halogenated benzoquinones in drinking water by suspension solidification dispersion liquid-liquid microextraction and liquid chromatography-mass mpectrometry
Objective To develop a suspension solidification dispersion liquid microextraction by liquid chromatography-mass spectrometry method for 9 types of chlorobenzoquinones in drinking water.Methods After 10 ml water was added into 1.5 g NaCl,the dispersed liquid-liquid microextraction was carried out by 20 μl 1-dodecanol which 0.3 ml methanol was the dispersant.After centrifugation,the extractant was solidified in a refrigerator at-20 ℃.Then re-solubilized was operated by adding 80 μl methanol when draining the water.The nine halogenated quinones were analyzed with the mobile phases of methanol and 0.2％formic acid in water,and then separated on an Acclaim TM RSLC120 C18 column(2.1 mmx100 mm,2.2μm).The detection was performed in electrospray negative ionization mode and multiple reaction monitoring(MRM)mode by quadrupole tandem mass spectrometer,and quantificated by tht external standard method.Results Nine chlorobenzoquinone compounds exhibited good linearity in the concentration range of 50-2 000 ng/L,with correlation coefficients not less than 0.99.The recoveries of the nine chlorobenzoquinone compounds spiked at three spiked levels were in the range of 79.6％-121.3％with the relative standard deviations(RSDs)of 4.4％-14.7％;the limits of detection were 4-20 ng/L.Conclusion The method is simple and fast,and it can be used for the simultaneous detection of 9 chlorobenzoquinones in drinking water.
Solidification floating organic droplet dispersion liquid microextractionHalogenated benzoquinoneLiquid mass spectrometryDrinking water
万方数据
维普
