Determination of lithium content by inductively coupled plasma-mass spectrometry in blood and urine
Objective Inductively coupled plasma-mass spectrometry was used to explore and study the influencing factors in the determination of lithium content in biological samples.It was established a simple and rapid method for determining the concentration of lithium ions in blood and urine.Methods Urine and blood samples were directly diluted 12.5 times/20 times using 1％nitric acid/0.1％triton X-100-1％nitric acid solution,scandium(Sc)was used as the internal standard element to complete the detection in standard mode.Results The method uses standard curve to determinate lithium content in biological samples,the linear range of this method was 0.03-50.0 μg/L,the correlation coefficient was 0.999 9,the detection limits were 0.008 μg/L,the recoveries of samples were 86.1％-103.8％,the precisions were 0.8％-4.2％,quality control samples were measured satisfactorily.Conclusion A simple and rapid method for determining lithium content in biological samples were established in this study.The influencing parameters in the experiment are optimized and studied,and the influence of the changes of each parameter on the experimental results is discussed in detail.This method has the advantages of simple and fast operation,with high sensitivity,good stability,low detection limit and a wide range of application,which is suitable for the determination of lithium content of biological samples in various populations.
万方数据
维普
