摘要
目的 建立尿液中16种稀土元素(包括镧、铈、镨、钕、铕、钆、镝、钐、铽、钬、铒、铥、镱、镥、钪和钇)的电感耦合等离子体质谱同时测定法.方法 尿液经1％硝酸直接稀释10倍后过滤,选择ICP-MS标准模式和标准加入法进样测定稀土元素的浓度.结果 钪的线性范围为0.1～10 μg/L,其余15种稀土元素的线性范围为0.05～10 μg/L,所得回归方程的线性关系良好,r＞0.999.方法的检出限为0.017～0.215 μg/L,定量下限为0.052～0.718 μg/L;加标回收率为92.1％～107.2％,RSD为0.2％～7.4％.结论 该方法准确、快速、稳定且灵敏度高,适用于尿液中16种稀土元素的同时分析.
Abstract
Objective To establish a test method for simultaneous determination of 16 rare earth elements in urine by inductively coupled plasma mass spectrometry,including lanthanum,cerium,praseodymium,neodymium,europium,gadolinium,dysprosium,samarium,terbium,holmium,erbium,thulium,ytterbium,lutetium,scandium and yttrium.Methods The urine was diluted 10 times with 1％nitric acid and then filtered,ICP-MS standard mode and standard addition method were used to determine the concentration of rare earth elements.Results The linear range of scandium was 0.1-10 μg/L,and the linear range of the remaining 15 rare earth elements was 0.05-10 μg/L,the linear relationship of regression equation was good,r＞0.999.The limit of detection was 0.017-0.215 μg/L,the limit of quantitations were 0.052-0.718 μg/L.The recoveries were 92.1％-107.2％.The RSDs were 0.2％-7.4％.Conclusion This method is accurate,rapid,stable and highly sensitive and is applicable to the simultaneous analysis of 16 rare earth elements in urine.
基金项目
2022年嘉定区卫生健康委科研立项项目(2022-KY-25)
维普
万方数据