Th17/Treg cell imbalance and effects on autoimmune hepatitis:a review of recent studies
Autoimmune hepatitis(AIH)is a chronic liver inflammatory disease characterized by elevated serum autoantibody level and immune dysfunction.Its pathogenesis has not been fully illustrated,and it is known to be involved in environmental factors,heredity factors,dynamic immunological microenvironment and other factors.Th17 cells and Treg cells are two important subsets related to immunity,which are functionally antagonistic to each other.Th17 is pro-inflammatory and Treg is anti-inflammatory.Th17/Treg imbalance is an important characteristic of AIH,which plays a crucial part in the occurrence and development of autoimmune hepatitis.Regulating Th17/Treg imbalance is a new target for treating AIH.In the present paper,Th17/Treg cell imbalance and its regulatory role in the progression and development of AIH are reviewed,and it proposes exploring intervention drugs that down-regulate Th17 or up-regulate Treg to develop effective therapies,to provide new targets for the treatment and prevention of AIH.
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