Association between ambient ozone and lung cancer mortality in Nanjing:a time-series analysis
Objective To understand the effect of atmospheric ozone(O3-8h)on lung cancer mortality in Nanjing City and its lag effects.Methods The data from 2013 to 2020 on daily lung cancer deaths in Nanjing City were collected,along with daily maximum 8-hour concentrations of ozone and other pollutants(PM2.5,PM10,NO2,CO,SO2)and the meteorological data.Time series analysis methods were used,employing a combination of Poisson distribution and a generalized additive model to control for long-term and seasonal trends,meteorological factors and weekday effects.The excess risk(ER)of lung cancer mortality per 10 μg/m3 increase in atmospheric O3-8 h was calculated,and stratified analysis was performed by age,gender and education.Results Over the study period,Nanjing City recorded 24 107 lung cancer deaths,averaging 8 daily deaths,with males accounting for 72.20％.The median daily concentration of atmospheric O3-8h was 92.11 μg/m3.O3-8h was negatively correlated with PM2.5,NO2,and CO(P＜0.05).In the single-pollutant model,the highest impact of atmospheric O3-8h concentration per 10μg/m3 increase on lung cancer mortality was observed at lag 1 day,with an ER of 0.50％(95％CI:0.10％-0.90％).In the two-pollutant model,when other pollutants(PM2.5,NO2,CO,and SO2)were included,atmospheric O3-8 h showed varying degrees of changes in lung cancer mortality(P＜0.05).The excess risks of lung cancer mortality for the residents aged over 60 and those with lower educational levels increased by 0.54％(95％C/:0.10％-0.97％)and 0.47％(95％CI:0.05％-0.88％),respectively,with significant differences(P＜0.05).Conclusion Atmospheric O3-8h pollution is an independent risk factor for lung cancer mortality in Nanjing City,especially among the old residents and those with lower education levels,requiring special attention.
万方数据
维普
