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机动车尾气颗粒物的健康效应及机制研究进展

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随着人类社会的不断进步发展,为了适应生产生活的需要,机动车也随之变得越来越普及,机动车尾气在2014年被列为2B级致癌物,其中柴油车尾气颗粒物在2012年从2A类致癌物升为1类致癌物.机动车尾气中的颗粒物还会吸附不同种类的致癌物,进一步加强对人体的危害.流行病学研究表明,机动车尾气对循环系统、呼吸系统、神经系统及生殖系统产生损伤效应并诱导疾病的发生,此外机动车尾气还与炎症反应的发生以及一些细胞蛋白的表达翻译异常有密切关系.目前对于机动车尾气有关健康效应的研究尚处于发展阶段,机动车尾气及其他污染物联合毒性效应及机制的研究还需要进一步探讨.该文综述了近年来机动车尾气颗粒物的健康效应及机制研究进展.
Health effects and mechanism of motor vehicle exhaust particulates:a review of recent studies
With the continuous progress and development of human society,in order to meet the needs of human production and life,motor vehicles have become more and more popular,motor vehicle exhaust was listed as 2B class carcinogen in 2014,of which diesel vehicle exhaust particulate matter was upgraded from 2A carcinogens to 1 class carcinogens in 2012.The particulate matter in motor vehicle exhaust will also adsorb different types of carcinogens,further enhancing the harm to the human body.Epidemiological studies have shown that motor vehicle exhaust has a damaging effect on the respiratory system,circulatory system,nervous system and reproductive system and inducing the occurrence of diseases.In addition,motor vehicle exhaust is also closely related to the occurrence of inflammatory response,as well as the abnormal expression and translation of some cellular proteins.At present,the research on the health effects of motor vehicle exhaust is still in the development stage,and the research on the combined toxic effects and mechanisms of motor vehicle exhaust and other pollutants needs to be further explored.In this paper,the related studies that have been conducted in recent years were reviewed in detail.

Atmospheric particulate matterMotor vehicle exhaust particlesHealth effects

陈中豪、王新怡、刘梦可、吕正梅、王牧笛

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安徽医科大学基础医学院组织胚胎学教研室,安徽合肥 230032

安徽医科大学第二临床医学院

大气颗粒物 机动车尾气颗粒 健康效应

安徽高校自然科学研究项目安徽医科大学博士科研资助基金

KJ2021A0209XJ201923

2024

环境与健康杂志
中华预防医学会,天津市疾病预防控制中心

环境与健康杂志

CSTPCD
影响因子:0.658
ISSN:1001-5914
年,卷(期):2024.41(6)