Risk of ischemic heart disease caused by atmosphere carbon monoxide in Liuzhou City:a prospective cohort study
Objective To understand the relationship between atmospheric pollutantsexposure,including carbon monoxide(CO),sulfur dioxide(SO2),nitrogen dioxide(NO2)and the risk of ischemic heart disease(IHD).Methods Using the Liuzhou sub-cohort from the China Kadoorie Biobank(CKB)Prospective Study,a time-series distributed lag nonlinear model was constructed to analyze the association between atmospheric pollutants and the risk of IHD.Results The association between CO exposure and theincidence of IHD was statistically significant.With a 1 mg/m3 increase in CO concentration,the maximum single-day lag effect was associated with a 1.102％increase in IHD risk(95％CI:1.010％-1.202％,lag 1 day),and the maximum cumulative lag effect was associated with a 1.375％increase in IHD risk(95％CI:1.038％-1.821％,lag 03 days).The effects of CO,SO2 and NO2 on IHD risk were more pronounced during the cold season,and individuals aged ≥60,engaging in physical exercise ≥3 times per week,and retirees were more susceptible to the impact of CO.Conclusion Exposure to the air pollutant CO may increase the risk of IHD.It is necessary to take measures to reduce CO concentration in order to decrease the risk of IHD.
Air pollutantsIschemic heart diseaseTime-series analyze
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