Effects of air pollution and meteorological factors on number of coronary heart disease,diabetes mellitus and cerebral infarction attendances in Xigu district,Lanzhou
Objective To understand the effects of atmospheric pollutants and meteorological factors on the incidence of coronary heart disease,diabetes mellitus,and cerebral infarction visits in Xigu district,Lanzhou City.Methods This study employed a time-stratified case-crossover design with 1∶1-1∶3 one-way retrospective case matching and 1∶1-1∶6 two-way case matching,incorporating a lag time of 0-7 days.The optimal lag period for atmospheric pollutants and meteorological factors was determined based on the principle of maximum odds ratio(OR).The effects of these factors on coronary heart disease,diabetes mellitus,and cerebral infarction were analyzed by using a Cox regression model.Results Among all control matches,the air pollution and meteorological factors exhibited the most significant impact on cerebral infarction,as indicated by the largest odds ratio(OR)value observed with the one-way retrospective 1∶1 control match.Specifically,air quality index(AQI),carbon monoxide(CO),O3-8h,PM2.5,air temperature,and air pressure were identified as risk factors influencing visits from patients with coronary heart disease,with the highest OR value of 5.517(95％CI:2.189-13.903)corresponding to each 10 mg/m3 increase in CO concentration.Furthermore,AQI,CO,O3-8 h,and temperature were recognized as the risk factors affecting the treatment of diabetic patients,where the largest OR value for diabetes mellitus,at 3.430(95％CI:1.889-6.229),was also linked to a 10 mg/m3 increase in CO concentration.In patients with cerebral infarction,AQI,CO,SO2,O3-8 h,air temperature,and air pressure were identified as the risk factors impacting treatment,the highest OR value for cerebral infarction was 3.093(95％CI:1.355-7.060)for each 10 mg/m3 increase in CO concentration.Notably,the effects of air pollutants on the incidence of coronary heart disease,diabetes mellitus and cerebral infarction were most pronounced at a lag of seven days.Conclusion AQI,CO,O3-8 h,air temperature and barometric pressure are identified as the risk factors for episodes of coronary heart disease,diabetes mellitus and cerebral infarction among permanent residents of Xigu district,Lanzhou City.Among these,CO exhibit the highest degree of correlation with coronary heart disease,diabetes mellitus and cerebral infarction.
Air pollutantsCoronary heart diseaseDiabetes mellifluousCerebral infarctionCase-crossover studyCox regression
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