Role of macrophage activation in pulmonary fibrosis induced by PM2.5:a review of recent studies
PM2.5 is one of the main components of atmospheric pollutants,inhaled by the human body can reach the lungs along the bronchus,dispersed deposition in the alveolar lining,causing alveolar epithelial cell damage.And then it can induce fibroblasts to multiply and transform into myofibroblasts,resulting in pulmonary fibrosis.As the first line of defense against PM2.5 in the respiratory system,pulmonary macrophages have strong plasticity and heterogeneity,and play a crucial role in the process of PM2.5 induced fibrosis.In this paper,the pathological role of pulmonary macrophages in the process of PM2.5 induced pulmonary fibrosis and its research progress were reviewed by referring to the relevant literatures at home and abroad in recent years,in order to provide the reference for the targeted treatment of pulmonary fibrosis.
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