18F-FDOPA compared 18F-FDG MicroPET/CT imaging in diagnosis of pheochromocytoma in nude mice
Objective To compare the imaging value of 18F-FDOPA and 18F-FDG for pheochromocytoma bearing tumor.Methods Totally 8 nude mouse models bearing tumor were established.Each nude mouse was injected with 18.5 mBq of 18F-FDOPA solution through the tail vein,and MicroPET/CT scan was performed 30 min,60 min,90 min and 120 min respectively.After 24 h interval,18F-FDG developer 18.5 mBq was injected again,and microPET/CT scan was performed after 30 min,60 min,90 min and 120 min,respectively.The maximum standard uptake value(SUVmax)and the radioactivity uptake ratio(T/NT)of tumor to non-tumor tissue imaged with different imaging agents were measured by mapping areas of interest.Results After intravenous injection of 18F-FDOPA in 8 nude mice 30 min,60 min,90 min,120 min,the tumor could be clearly demonstrated,and the SUVmax was 5.99±0.54,6.05±0.52,6.23±0.66,6.28±0.60,respectively.There was no significant difference among all time points(P＞0.05).After injection of 18F-FDG 30 min,60 min,90 min and 120 min,the SUVmax of tumor was 2.04±0.24、2.33±0.27、2.22±0.42、2.13±0.31,respectively,and there was no statistical significance at each time point(P＞0.05).The SUVmax of 18F-FDOPA for pheochromocytoma was higher than that of 18F-FDG(P＜0.01).After injection of 18F-FDOPA and 18F-FDG for 60 min,the ratio of tumor to brain,heart and muscle of 18F-FDOPA was higher than that of 18F-FDG,with significant differences(P＜0.05).Conclusion 18F-FDOPA PET/CT has good imaging effect in the diagnosis of pheochromocytoma tumor bearing nude mouse model and is superior to 18F-FDG in terms of SUVmax and T/NT.
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