Role of mitochondrial fusion in diabetic cardiomyopathy:a review of recent studies
Diabetic cardiomyopathy(DCM)is a major cardiovascular complication of diabetes mellitus.The pathogenesis is complex,and there is still a lack of effective prevention and treatment measures in clinical practice.In recent years,more and more studies have shown that mitochondrial swelling and internal tissue destruction occur in DCM,and mitochondrial fusion regulates mitochondrial structure and function,which is involved in the regulation of myocardial structure and function,suggesting that mitochondrial fusion plays an important role in the occurrence and development of DCM.The present paper systematically described the mechanism of mitochondrial fusion affecting the progression of DCM by regulating mitochondrial dynamics,apoptosis,oxidative stress and insulin resistance,so as to provided new ideas and methods for the prevention and treatment of DCM in the future.
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