N6-methyladenosine methylation(m6A)is one of the most common epigenetic post-transcriptional modifications of eukaryotic RNA.Under the joint action of RNA methyltransferases,demethylases and their binding proteins,m6A modifications dynamically and reversibly regulate the metabolic processes of mRNA,lncRNA and miRNA,which are closely related to the occurrence and development of female reproductive system tumors.In the present paper,the concept,function and regulatory mechanism of m6A RNA methylation modification in female reproductive system tumors and its association with exogenous environmental factors were reviewed in detail,for providing new ideas for the prevention and itervention m6A-targeted female reproductive system tumors.
关键词
m6A甲基化/生殖系统肿瘤/外源因素
Key words
m6A methylation/Tumors of reproductivesystem/Exogenous factors
维普
万方数据