Risk factors of senile degenerative heart valve disease in elderly people in China:a Meta-analysis
Objective To explore risk factors of senile degenerative heart valve disease(SDHVD)in the elderly in China by Meta analysis.Methods Meta-analysis was conducted according to preferred reporting items for systematic reviews and Meta-analyses(PRISMA)guidelines for systematic review and Meta-analysis.Eleven electronic databases,including PubMed,Web of Science,Cochrane,Embase,Ovid,Scopus,CNKI,VIP database,Wan Fang database,The National Medical Journal of China,and SinoMed database,were retrieved from their inception to March 15,2023.The articles about SDHVD were searched systematically.Literature screening,quality evaluation and data extraction were independently conducted by 2 researchers according to the inclusion and exclusion criteria.Meta-analysis was performed by Stata17.0.Results A total of 18 articles(including cross-sectional study and case-control study)were included,involving 10 121 elderly people.After controlling the confounding variables,the following risk factors were related to SDHVD in elderly people in China:age(WMD=4.29,95% CI:1.84-6.74,I2=94.5% ,P<0.05),smoking(OR= 1.32,95% CI:1.00-1.73,I2=78.9% ,P<0.05),hypertension(OR=1.93,95% CI:1.75-2.13,I2=0,P<0.001),hyperlipidemia(OR=1.66,95% CI:1.40-1.97,I2=2.4% ,P<0.001),diabetes mellitus(OR=1.33,95% CI:1.05-1.69,I2=60.6% ,P<0.05),coronary artery disease(OR=2.12,95% CI:1.60-2.80,I2=67.4% ,P<0.001),osteoporosis(OR=3.42,95% CI:2.07-5.65,I2= 0,P<0.001),blood phosphorus(OR=-0.02,95% CI:-0.05-0.02,I2=0,P>0.05).Conclusion Age,smoking,hypertension,hyperlipidemia,diabetes mellitus,coronary artery disease,and osteoporosis are the risk factors of SDHVD in elderly people.
China areaElderlySenile degenerative heart valve diseaseRisk factorsMeta analysis
NETL
NSTL
万方数据
维普
