Effects of Zhenpi decoction on mucosal lesions and inflammation in patients with ulcerative colitis at remission stage
Objective To study the effect of Zhenpi decoction on mucosal lesions and inflammatory in patients with ulcerative colitis(UC)at remission stage.Methods A total of 90 remission-stage UC patients admitted to Wujin Hospital Affiliated to Jiangsu University(Wujin Clinical College of Xuzhou University)from August 2019 to July 2022 were enrolled.They were divided into observation group and control group by random number table,with 45 cases in each group.The control group was given mesalazine enteric-coated tablet,and the observation group was given Zhenpi decoction,both for 3 consecutive months.Colonoscopy was performed 3 months after treatment.Clinical effect,traditional Chinese medicine(TCM)syndrome score,the severity of mucosal lesions,serum levels of inflammatory factors(interleukin 6[IL-6],interleukin 23[IL-23],tumor necrosis factor-alpha[TNF-α],hypersensitive C-reactive protein[hs-CRP]),the number of intestinal flora(Bifidobacterium,Lactobacillus,Escherichia coli,Enterococcus faecalis),the incidence and recurrence rates of adverse reactions(nausea and vomiting,dizziness and headache,fatigue and belching)during medication were compared between the 2 groups.Results The total effective rate in the observation group was significantly higher than that in the control group(P<0.05).There were no significant differences in the scores of diarrhea,abdominal pain,mucous pus and blood stool,tenesmus or Baron score between the 2 groups before treatment(P>0.05).After 3-month treatment,the above indexes were significantly decreased in both groups(P<0.05),and the above scores in the observation group were significantly lower than those in the control group(P<0.05).There were no significant differences in hs-CPR,IL-6,TNF-α or IL-23 levels between the 2 groups before treatment(P>0.05).The levels of the above indexes were significantly decreased after 3-month treatment in both groups(P<0.05),and the levels of the above indexes in the observation group were significantly lower than those in the control group(P<0.05).There were no significant differences in the numbers of Bifidobacteria,Lactobacillus,Escherichia coli,or Enterococcus faecalis between the 2 groups before treatment(P>0.05).After 3-month treatment,the numbers of Bifidobacteria and Lactobacillus were significantly increased,while the numbers of Escherichia coli and Enterococcus faecalis were significantly decreased in both groups(P<0.05).After 3-month treatment,the numbers of Bifidobacteria and Lactobacillus were significantly increased,the numbers of Escherichia coli and Enterococcus faecalis were significantly decreased(P<0.05);and the observation group had more Bifidobacteria and Lactobacillus and less Escherichia coli and Enterococcus faecalis than the control group(P<0.05).The total incidence of adverse reactions and recurrence rate in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Zhenpi decoction can effectively relieve intestinal mucosal lesions,reduce gastrointestinal inflammation and balance intestinal flora at UC remission stage.
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