Value of hemocoagulase in pre-hospital care for patients with multiple trauma
Objective To explore the value of hemocoagulase in pre-hospital care for patients with multiple trauma.Methods A total of 104 patients with multiple trauma admitted to Beijing Emergency Medical Center from April 2019 to April 2022 were selected as study objects.They were divided into observation group(n=52,routine pre-hospital emergency treatment with hemocoagulase)and control group(n=52,routine pre-hospital emergency treatment).The hemostatic time,average blood loss,unit area bleeding,hemoglobin(Hb),hematocrit(HCT),platelet aggregation rate(PAR),prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB),D-dimer(D-D),antithrombin Ⅲ(AT-Ⅲ),tissue plasminogen activator(t-PA),plasminogen activator inhibitor-1(PAI-1),complications,and adverse reactions were compared between the two groups.Results The hemostatic time,average blood loss,and unit area bleeding in the observation group were significantly less than those in the control group(P＜0.05).The Hb,HCT,and PAR after treatment were significantly lower than those before treatment in the two groups,but the Hb,HCT and PAR after treatment in the observation group were significantly higher than those in the control group(P＜0.05).There was no significant difference in PT,APTT,FIB,D-D,PAI-1,AT-Ⅲ,or t-PA between the two groups before and after treatment(P＞0.05).There was no significant difference in the total incidence of complications between the two groups(P＞0.05).The mortality rate of the observation group was significantly lower than that of the control group(P＜0.05).The incidence of adverse reactions was 5.77%in the observation group and 0 in the control group(χ2=3.089,P=0.079).Conclusion The application of hemocoagulase in pre-hospital emergency treatment in patients with multiple trauma can reduce bleeding,and has no significant impact on the coagulation and fibrinolysis.It had good safety and is conducive to the improvement of prognosis.
HemocoagulaseMultiple traumaPre-hospital careOutcomeCoagulation function
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