超声内镜、巨噬细胞抑制因子-1、糖类抗原19-9联合诊断胰腺癌的临床价值分析
Combined use of endoscopic ultrasound,MIC-1 and CA19-9 in diagnosis of pancreatic cancer
郑舒丹 1杨柳1
作者信息
- 1. 215000 江苏 苏州,南京医科大学附属苏州市立医院消化内科
- 折叠
摘要
目的 探究超声内镜、巨噬细胞抑制因子-1(MIC-1)、血清肿瘤标志物糖类抗原 19-9(CA19-9)联合诊断胰腺癌的临床价值.方法 选取 2019 年 3 月至 2022 年 3 月在南京医科大学附属苏州市立医院行超声内镜检查的 100 例高度疑似胰腺癌患者作为观察组,同期来院进行体检的 50 例健康志愿者作为对照组.采用化学发光法检测CA19-9 水平,采用酶联免疫法检测MIC-1 水平并进行组间比较.以术后患者的病理检查结果为金标准,比较超声内镜、MIC-1、CA19-9 分别及联合应用对胰腺癌的诊断价值.结果 2 组研究对象的血清CA19-9、MIC-1 水平比较差异有统计学意义(P＜0.05).与健康对照组相比较,观察组患者的血清CA19-9、MIC-1 水平更高,差异有统计学意义(P＜0.05).超声内镜、MIC-1、CA19-9 三者联合诊断的敏感度(84.21%)均低于三者分别诊断(92.11%、90.79%、90.79%),特异度(91.67%)均高于三者分别诊断(79.17%、83.33%、75.00%).三者联合诊断的阳性预测值为 96.97%,阴性预测值为 64.71%.结论 在对胰腺肿瘤进行良恶性诊断时,采用超声内镜、MIC-1、CA19-9 联合诊断可以有效提高其诊断效能.
Abstract
Objective To explore the diagnostic value of endoscopic ultrasound combined with macrophage inhibitory factor-1(MIC-1)and serum tumor-marker carbohydrate antigen 19-9(CA19-9)in pancreatic cancer.Methods One hundred patients with highly suspected pancreatic cancer(observation group)who underwent endoscopic ultrasonography at Suzhou Municipal Hospital between March 2019 and March 2022 and 50 healthy volunteers(control group)were enrolled in this study.Their CA19-9 levels were detected by chemiluminescence and MIC-1 levels were measured by enzyme-linked immunoassay.Pathological results of patients after surgery were taken as the golden standard.The diagnostic value of endoscopic ultrasound,MIC-1 or CA19-9 and their combined evaluation in pancreatic cancer was analyzed.Results Serum CA19-9 and MIC-1 levels in the observation group were significantly higher than those in the control group(P＜0.05).The sensitivities of endoscopic ultrasound,MIC-1,and CA19-9 in diagnosis of pancreatic cancer was 92.11%,90.79%,and 90.79%,respectively,which were higher than their combined evaluation(84.21%).The specificity of endoscopic ultrasound,MIC-1,and CA19-9 in diagnosis of pancreatic cancer were 79.17%,83.33%,and 75.00%,respectively,which were lower than their combined evaluation(91.67%).The positive predictive value of combined evaluation was 96.97%,and the negative predictive value was 64.71%.Conclusion In the diagnosis of pancreatic cancer,combined use of endoscopic ultrasound,MIC-1 and CA19-9 can effectively improve the diagnostic efficiency.
关键词
超声内镜/巨噬细胞抑制因子-1/血清肿瘤标志物/CA19-9/胰腺癌Key words
Endoscopic ultrasound/Macrophage inhibitory factor-1/Serum tumor marker/CA19-9/Pancreatic cancer引用本文复制引用
出版年
2024
NETL
NSTL
万方数据