Expression levels of serum GASP-1,lipocalin-2 and TPX2 in lung cancer and their correlations with TNM stage and prognosis
Objective To investigate the expression levels of serum G protein-coupled receptor-associated sorting protein 1(GASP-1),lipocalin-2(LCN2)and targeting protein for Xenopus kinesin-like protein 2(TPX2)in lung cancer patients,and their correlations with tumor-node-metastasis classification(TNM)pathological stage and prognosis.Methods A total of 92 patients with lung cancer who were admitted to General Hospital of Southern Theatre Command from April 2019 to May 2022 were selected as observation group.Meanwhile,92 healthy subjects were selected as control group.Peripheral venous blood samples of the two groups were collected to detect serum GASP-1,LCN2 and TPX2 levels.Serum GASP-1,LCN2 and TPX2 levels of lung cancer patients with different TNM stages were analyzed.According to the prognosis,the patients were divided into good prognosis group and poor prognosis group.Serum GASP-1,LCN2 and TPX2 levels were compared between the two groups.The correlations of serum GASP-1,LCN2 and TPX2 levels with TNM stage and prognosis in patients with lung cancer were investigated.Results The serum GASP-1,LCN2 and TPX2 levels in the observation group were significantly higher than those in the control group(P＜0.05).The serum levels of GASP-1,LCN2 and TPX2 in patients with TNM stage Ⅲ and Ⅳ were significantly higher than those in patients with TNM stage Ⅰand Ⅱ(P＜0.05).The levels of serum GASP-1,LCN2 and TPX2 in patients with TNM stage Ⅳ were significantly higher than those in patients with TNM stage Ⅲ(P＜0.05).Serum GASP-1,LCN2 and TPX2 levels in the good prognosis group were significantly lower than those in the poor prognosis group(P＜0.05).Serum GASP-1,LCN2 and TPX2 levels were positively correlated with TNM stage before treatment(P＜0.05),but were negatively correlated with the prognosis after treatment(P＜0.05).Conclusion Serum levels of GASP-1,LCN2 and TPX2 may be related to the TNM pathological stages of lung cancer patients.The detection of the above serum indicators after treatment can reflect the prognosis of patients to a certain extent,and provide reference for clinical practice.
Lung cancerG protein-coupled receptor-associated sorting protein 1Lipocalin-2Targeting protein for Xenopus kinesin-like protein 2TNM stage
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