Clinical significance of the detection of lactate dehydrogenase and immunoglobulins in peripheral blood of children with recurrent bronchopneumonia
Objective To explore the clinical significance of lactate dehydrogenase(LDH)and immunoglobulin levels in peripheral blood of children with recurrent bronchopneumonia.Methods A total of 120 children with bronchopneumonia admitted to The People's Hospital of Rugao from April 2019 to April 2022 were selected as research objects and assigned to study group.According to the number of attacks,the patients were divided into recurrent attack subgroup(n=51,bronchopneumonia attacks≥2 times within 1 year)and nonrecurrent attack subgroup(n=69).Meanwhile,40 healthy children undergoing physical examination in our hospital were selected and assigned to control group.The levels of LDH,serum immunoglobulin M(IgM),immunoglobulin G(IgG)and immunoglobulin A(IGA)were analyzed.Clinical data were compared between the recurrent attack subgroup and nonrecurrent attack subgroup.Logistic regression analysis was used to analyze the influencing factors of the recurrent attack of bronchopneumonia.Results The study group had higher level of LDH and lower levels of IgM,IgG and IgA than the control group(P＜0.01).The recurrent attack subgroup had higher level of LDH and lower levels of IgM,IgG and IgA than the nonrecurrent attack subgroup(P＜0.01).There was no significant difference in terms of age,sex,height,weight,heart rate,body temperature,white blood cell count,living environment,family history,type of bronchopneumonia,smoking of the main caregivers or excessive use of antibiotics between the recurrent attack subgroup and nonrecurrent attack subgroup(P＞0.05).Logistic regression analysis showed that LDH,IgM,IgG and IgA were the related factors of recurrent bronchopneumonia(OR=3.747,3.056,4.860,4.272,P＜0.01).Conclusion The levels of LDH in peripheral blood of children with recurrent bronchopneumonia are abnormally increased,and the levels of IgG,IgA and IgM are abnormally decreased.The levels of LDH,IgG,IgA and IgM in peripheral blood can be used as biochemical indicators to predict recurrent bronchopneumonia in children.
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