Objective To investigate the effects of radiofrequency and laser ablation on treating great saphenous varicose veins.Methods Totally 280 patients with great saphenous varicose veins who underwent vascular surgery in Department of Vascular Surgery,Huguosi Hospital Affiliated to Beijing University of Chinese Medicine,Beijing from January 2018 to January 2021 were selected as research subjects,and were divided into the radiofrequency group and laser group according to different surgical methods.The radiofrequency group(140 patients and 140 affected limbs)was treated with radiofrequency ablation(RFA)with great saphenous vein+ foam sclerosing agent injection+point stripping.The laser group(140 patients and 140 affected limbs)was treated with high ligation with great saphenous vein+endovenous laser ablation + foam sclerosing agent injection+point stripping.The surgical time,intraoperative blood loss,hospital stay,PLT,D-D,visual analogue scale(VAS)score,venous clinical severity scale(VCSS)score,complication rate,great saphenous vein closure and recurrence were compared between the patients of the 2 groups.Results The surgical time,hospital stay and intraoperative blood loss of the patients in the radiofrequency group were less or shorter than those in the laser group,with statistical significance(P<0.05).After treatment,the D-D level in the two groups were lower than those before treatment,the PLT level of radiofrequency group was lower than this before treatment,the PLT level of laser group was higher than this before treatment,and the PLT and D-D levels in the radiofrequency group were lower than those in the laser group,also with statistical significance(P<0.05).The VAS scores of the patients in the radiofrequency group at hour 6 and hour 48 after surgery were lower than those in the laser group,and there was also statistical significance,when comparisons were made between them(P<0.05).There was no statistical significance in preoperative VCSS scores between the two groups(P>0.05).One month after surgery,the VCSS scores of the patients in the radiofrequency group were significantly lower than those of the patients in the laser group,also with statistical significance(P<0.05).There were no significant differences in postoperative closure and recurrence,when comparisons were made between the two groups(P>0.05).The rate of postoperative complications in the radiofrequency group was significantly lower than that in the laser group,also with statistical significance(P<0.05).Conclusion The application of RFA for treatment of great saphenous varicose veins could reduce PLT and D-D levels of the patients after surgery,effectively control the severity of veins,and reduce the rate of complications.More importantly,it is more minimally invasive without high ligation of great saphenous vein.