首页|非酒精性脂肪性肝病患者血清γ-谷氨酰转肽酶与代谢综合征及血尿酸的相关性

非酒精性脂肪性肝病患者血清γ-谷氨酰转肽酶与代谢综合征及血尿酸的相关性

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目的 探讨非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)患者血清γ-谷氨酰转肽酶(γ-glutamyl-transferase,γ-GT)水平与代谢综合征(metabolic syndrome,MS)、血尿酸(uric acid,UA)水平之间的相关性.方法 161 例NAFLD患者按初次血清γ-GT生化检测结果分成γ-GT升高组和γ-GT正常组,整理 2 组的人口学特征,检测MS各组分及血UA水平.根据体重指数(body mass index,BMI)、各生化指标、MS患病情况依次分组比较正常组和异常组NAFLD患者血清γ-GT升高发生率,探索NAFLD患者血清γ-GT升高与MS各组分、血UA水平的相关性.结果 γ-GT升高组NAFLD患者的收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)、血UA以及包括三酰甘油(triglyceride,TG)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、LDL-C/高密度脂蛋白胆固醇比值(LDL-C/high-density lipoprotein cholesterol,LDL-C/HDL-C)、空腹血糖(fasting plasma glucose,FPG)、糖化白蛋白(glycosylated albumin,GSA)在内的MS各组分指标均高于γ-GT正常组(P<0.05).检验分析显示在高TG血症组、LDL-C升高组、高血糖组、高UA血症组、MS组,NAFLD患者血清γ-GT升高的发生率均增加(P<0.05).进一步控制年龄、性别因素后,NAFLD患者血清γ-GT水平与血UA和MS各组分(除HDL-C外)指标水平呈正相关(P<0.05).多元线性回归分析显示,血UA水平、MS组分个数与NAFLD患者血清γ-GT密切相关(P<0.05).结论 NAFLD患者血清γ-GT升高可反映其发生MS及高UA血症的风险增加.
Relationships between serum γ-glutamyltransferase and metabolic syndrome and serum uric acid in patients with nonalcoholic fatty liver disease
Objective To investigate the relationships between serum γ-glutamyltransferase(γ-GT)and metabolic syndrome(MS)and serum uric acid(UA)in patients with nonalcoholic fatty liver disease(NAFLD).Methods According to the initial blood biochemical test results,161 patients with NAFLD were divided into high γ-GT group and normal γ-GT group.The demographic characteristics,serum UA and MS related biochemical indexes of the two groups were analyzed.Results Systolic blood pressure(SBP),diastolic blood pressure(DBP),serum UA,triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),low-density lipoprotein cholesterol/high-density lipoprotein cholesterol(LDL-C/HDL-C),fasting plasma glucose(FPG)and glycosylated albumin(GSA)in the high γ-GT group were significantly higher than those in the normal γ-GT group(all P<0.05).Chi-square analysis showed that γ-GT was significantly increased in patients with hyperuricemia and elevated MS related biochemical indexes(all P<0.05).After further control of age and gender,serum γ-GT level was positively correlated with UA and MS components(except HDL-C)(P<0.05).Multiple linear regression analysis showed that serum UA level and the number of MS components were closely related to serum γ-GT in patients with NAFLD(P<0.05).Conclusion The increase of serum γ-GT is closely related to the increased risk of MS and hyperuricemia in NAFLD patients.

Nonalcoholic fatty liver diseaseγ-glutamyltransferaseMetabolic syndromeUric acid

王蒙蒙、苗雯蓉、陈英、韩易、楼标雷

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200052 上海,海军特色医学中心高压氧神经内科

非酒精性脂肪性肝病 γ-谷氨酰转肽酶 代谢综合征 尿酸

海军特色医学中心优秀青年教师引进人才项目海军特色医学中心"打仗型"基金(第二轮)海军特色医学中心"卓优人才工程优秀青年人才培养"项目(第一期)海军特色医学中心"强基计划"项目

2020SZ-2220M270221TPQN270123M2701

2024

10.3969/j.issn.1009-0754.2024.04.018

海军医学杂志
海军医学研究所

海军医学杂志

CSTPCD
影响因子：0.518
ISSN：1009-0754
年,卷(期)：2024.45(4)
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