Effect of anemia on prognosis in elderly patients with HBV-related decompensated cirrhosis
Objective To investigate the effect of anemia on the prognosis in elderly patients with hepatitis B virus(HBV)-related decompensated cirrhosis.Methods A total of 167 elderly patients with decompensated HBV-related liver cirrhosis who were treated in Haian People's Hospital from January 2015 to January 2018 were selected as research objects.There were 63 patients with anemia(anemia group)and 104 without anemia(non-anemia group).The clinical,laboratory and follow-up data of these patients were collected.The independent risk factors affecting the overall survival of the patients were identified using the univariate and multivariate Cox proportional hazards models.Results There were 33,27 and 3 cases of mild,moderate and severe anemia in the anemia group,respectively.The proportion of upper gastrointestinal bleeding,international normalized ratio,Child-Pugh score and model for end-stage liver disease-Na(MELD-Na)score in the anemia group were significantly higher than those in the non-anemia group(all P<0.05).The Kaplan-Meier curve showed that the median survival time of the anemia group was significantly shorter than that of the non-anemia group(39 months vs.51 months,P<0.001).Multivariate Cox regression analysis indicated that anemia(hazard ratio[HR]=2.79),hepatic encephalopathy(HR=1.77),upper gastrointestinal hemorrhage(HR=1.69)and MELD-Na score(HR=1.37)were independent risk factors affecting the overall survival of patients with HBV-related decompensated cirrhosis.Conclusion Anemia is associated with poor prognosis in elderly patients with HBV-related decompensated cirrhosis.The correction of anemia may help to improve the prognosis in these patients.
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