Correlation between chemoradiotherapy sensitivity and serum microRNA level in the patients with intermediate and advanced cervical cancer
Objective To investigate the correlation between chemoradiotherapy sensitivity and serum microRNA(miR)levels in the patients with intermediate and advanced cervical cancer.Methods Totally 112 patients with intermediate and advanced cervical cancer admitted to Nanchong Central Hospital from January 2020 to March 2022 were included in the study.All the patients were treated with synchronous radiochemotherapy.The sensitivity of the patients to the treatment regimen was analyzed,and the patients were divided into high sensitivity group(n=68)and low sensitivity group(n=44)in accordance with the sensitivity of the patients.The expression levels of serum miR-136,miR-664 and miR-206 in all patients were detected by real-time fluorescent quantitative PCR,and their expression levels were compared between the high sensitivity group and the low sensitivity group.The value of assessing the sensitivity to radiochemotherapy was evaluated by analyzing the expression levels of miR-136,miR-664 and miR-206 by receiver operating characteristic(ROC)curve.The relationship between radiochemotherapy sensitivity and clinical pathological features was analyzed,and influencing factors affecting sensitivity were explored in the patients with intermediate and advanced cervical cancer.Results The expression levels of miR-136 and miR-664 in the high sensitivity group were significantly higher than those in the low sensitivity group(P<0.05),and the expression level of miR-206 was significantly lower than that in the low sensitivity group(P<0.05).ROC curve results showed that serum miR-136,miR-664 and miR-206 all displayed a certain evaluation value for sensitivity of the patients,and the areas under the curve were 0.834,0.910 and 0.855,respectively.There was statistical significance in International Federation of Gynecology and Obstetrics(FIGO)staging when comparisons were made between the two groups(P<0.05).Multivariate Logistic regression analysis revealed that miR-136,miR-664,miR-206 and FIGO staging were all independent influencing factors of radiochemotherapy sensitivity in the patients with intermediate and advanced cervical cancer(P<0.05).Conclusion The expression levels of miR-136,miR-664 and miR-206 were correlated with the radiochemotherapy sensitivity of the patients with cervical cancer.The down-regulation of miR-136,miR-664 and the up-regulation of miR-206 might indicate radiochemotherapy resistance of cervical cancer.
Intermediate and advanced stageCervical cancerRadiochemotherapySensitivityMicro RNA
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