Prognostic factors of metastatic ovarian tumors of gastric and colorectal cancer
Objective To explore the clinical characteristics and factors affecting the prognosis of metastatic ovarian tumors of gastric and colorectal cancer.Methods Clinical data of 92 hospitalized patients with metastatic ovarian tumors of gastric and colorectal cancer in The First Affiliated Hospital of Naval Medical University from January 2010 to August 2020 were selected and analyzed retrospectively.The clinical characteristics,related laboratory data,survival and prognostic factors were statistically analyzed.Results There were less than half of carcinoembryonic antigen(CEA)-positive cases and less than half of carbolydrate antigen 125(CA125)-positive cases in the 92 cases.Medium-sized solid or cystic solid masses(5-10 cm)mainly presented on imaging.The median survival time of the patients was 16 months,and 1-,2-and 3-year overall survivals were 55.9%,36.8%and 17.6%,respectively.Univariate analysis showed that negative CA125,CA125/CEA<5,colorectal origin,adenocarcinoma of primary tumor,the resection of primary tumor,no external ovarian metastases,no residual of metastatic lesions after surgery,no vascular invasion of ovarian metastases,unilateral ovarian mass,ovarian mass less than 5 cm,ovarian metastases containing cystic components,and adenocarcinoma of ovarian metastases were related to a good prognosis.The expression of caudal type homeobox 2(CDX2)affected the survival time(P=0.001).COX regression multivariate analysis identified that the primary tumor site(P=0.023),ovarian mass<5 cm(P=0.031),and the expression of P53 in ovarian metastasis(P=0.007)were independent prognostic factors for metastatic ovarian tumors of gastric and colorectal cancer.Conclusion There is a wide range of onset age of patients with metastatic ovarian tumors of gastric and colorectal cancer.The clinical manifestations were nontypical,and medium-sized masses containing solid components mainly present on imaging.The prognosis is poor,but the patients with colorectal origin have better prognosis than patients with gastric origin.The prognosis of patients with ovarian mass<5 cm is good.The expression of P53 may be a protective factor for those patients.
NETL
NSTL
万方数据
