老年髋部骨折患者应用氟比洛芬酯与氯诺昔康的术后镇痛效果比较
Comparison of postoperative analgesic effects between flurbiprofen axetil and lornoxicam in elderly patients with hip fractures
李静 1常群 1朱顺 1肖洪敏1
作者信息
- 1. 236400 安徽 阜阳,临泉县人民医院药剂科
- 折叠
摘要
目的 探究老年髋部骨折患者应用氟比洛芬酯与氯诺昔康的术后镇痛效果.方法 随机选取临泉县人民医院在 2022 年 1 月至 2022 年 12 月间收治的 80 例老年髋部骨折患者纳入本次研究,用随机数字法将其分为对照组(40 例)和研究组(40 例).对照组予以氯诺昔康进行术后镇痛,研究组予以氟比洛芬酯进行术后镇痛.对比 2 组应激反应、镇痛效果、口服镇痛药物使用情况、用药安全性及髋关节恢复情况.结果 术前,2 组创伤应激指标水平比较差异无统计学意义(P>0.05);术后,2 组C反应蛋白(CRP)、皮质醇(Cor)、肾上腺素(AD)水平均高于术前,但研究组低于对照组(P<0.05).术前,2 组运动状态及静息状态下视觉模拟量表(VAS)评分比较差异无统计学意义(P>0.05);术后 1、12、24、48 h,2 组运动状态及静息状态下VAS评分均低于术前,且研究组均低于对照组(P<0.05).研究组口服镇痛药物使用少于对照组(P<0.05).2 组不良反应差异无统计学意义(P>0.05).术前,2 组髋关节活动度比较差异无统计学意义(P>0.05);术后 2 组髋关节活动度均优于术前(P<0.05),且研究组术后 4、8、12 周的髋关节活动度均优于对照组(P<0.05).结论 氟比洛芬酯的镇痛效果优于氯诺昔康,且能减少患者术后口服镇痛药物的使用,促进髋部功能恢复,其临床不良反应较少,具有较高安全性.
Abstract
Objective To compare the postoperative analgesic effects between flurbiprofen axetil and lornoxicam in elderly patients with hip fractures.Methods Eighty elderly patients with hip fractures who were admitted to the Linquan People's Hospital between January and December 2022 were randomly selected for this study.They were divided into control group and study group by random number method(n=40).Lornoxicam and flurbiprofen axetil were used for postoperative analgesia in the control group and study group,respectively.The stress response,analgesic effect,oral painkillers,medication safety,and hip joint recovery were compared between the two groups.Results There were no significant differences in trauma stress indicators,visual analogue scale was no significant difference in the range of motion of the hip joint between the two groups before operation.The postoperative range of motion of the hip joint was larger than preoperative one in both groups,and the range of motion in the study group was larger than that in the control group at 4,8 and 12 weeks after surgery(all P<0.05).Conclusion Flurbiprofen axetil exhibits better analgesic effect than lornoxicam.It can significantly reduce the use of oral painkillers after surgery and promote hip function recovery,with less adverse reactions and high safety.
关键词
老年髋部骨折/氟比洛芬酯/氯诺昔康/术后镇痛/不良反应Key words
Elderly hip fractures/Flurbiprofen axetil/Lornoxicam/Postoperative analgesia/Adverse reaction引用本文复制引用
出版年
2024
NETL
NSTL
万方数据