心源性休克患者血清解偶联蛋白2与血乳酸的相关性分析及两者对预后的预测价值
Correlation between serum uncoupling protein 2 and blood lactic acid in patients with cardiogenic shock and their prognostic values
赵博 1张欢2
作者信息
- 1. 213000 江苏常州,苏州大学附属常州老年病医院(常州市第七人民医院)重症医学科
- 2. 213000 江苏常州,苏州大学附属常州老年病医院(常州市第七人民医院)胸心外科
- 折叠
摘要
目的 探究心源性休克患者血清解偶联蛋白 2(UCP2)与血乳酸的相关性及两者对预后的预测价值.方法 选取苏州大学附属常州老年病医院 2017 年 3 月至 2022 年 4 月收治的 61 例心源性休克患者作为研究对象,分别采集患者入院时动脉血及外周静脉血,检测血乳酸和UCP2 水平,根据治疗 28 d后预后生存情况将其分为死亡组和存活组.分析UCP2 与血乳酸之间的相关性及两者对心源性休克预后的预测价值.以受试者操作特征(ROC)曲线评估血乳酸和UCP2 对心源性休克患者预后的预测价值.结果 死亡组患者UCP2、血乳酸、肌钙蛋白及胆红素水平均高于存活组,差异有统计学意义(P<0.05).Pearson相关分析结果显示,UCP2 与血乳酸呈正相关(r=0.529,P<0.05).Logistic回归分析结果显示,UCP2、血乳酸、肌钙蛋白及胆红素升高均为心源性休克预后的危险因素(P<0.05).ROC曲线分析显示,UCP2、血乳酸及二者联合预测心源性休克预后的AUC分别为 0.703、0.708、0.796.结论 在心源性休克患者病情进展中,UCP2 与血乳酸呈正相关,且UCP2、血乳酸对心源性休克预后具有较高的预测效能.
Abstract
Objective To explore the correlation between serum uncoupling protein 2(UCP2)and blood lactic acid in patients with cardiogenic shock and their prognostic value.Methods A total of 61 patients with cardiogenic shock treated in Department of Critical Care Medicine from March 2017 to April 2022 were selected as research objects.Arterial blood and peripheral venous blood were collected to examine the levels of blood lactic acid and UCP2 at admission.The patients were divided into death group and survival group according to the survival after 28 days of treatment.The correlation between UCP2 and blood lactate acid and the factors influencing the prognosis of cardiogenic shock were analyzed.The predictive value of blood lactate acid and UCP2 for the prognosis of cardiogenic shock was evaluated using receiver operating characteristic(ROC)curve.Results The levels of UCP2,blood lactic acid,troponin and bilirubin in the death group were significantly higher than those in the survival group(all P<0.05).Pearson analysis showed that UCP2 was positively correlated with blood lactate acid(r=0.529,P<0.05).Logistic analysis showed that the increase of UCP2,blood lactate,troponin and bilirubin were all risk factors for the prognosis of cardiogenic shock(all P<0.05).ROC curve showed that the AUC values of UCP2,blood lactate acid and their combination in predicting the prognosis of cardiogenic shock were 0.703,0.708 and 0.796,respectively.Conclusion UCP2 is positively correlated with blood lactate acid in the progression of cardiogenic shock.UCP2 and blood lactate acid have high predictive value for the prognosis of cardiogenic shock.
关键词
心源性休克/解偶联蛋白2/血乳酸/预后Key words
Cardiogenic shock/Uncoupling protein 2/Blood lactic acid/Prognosis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据