Objective To explore the correlation between serum uncoupling protein 2(UCP2)and blood lactic acid in patients with cardiogenic shock and their prognostic value.Methods A total of 61 patients with cardiogenic shock treated in Department of Critical Care Medicine from March 2017 to April 2022 were selected as research objects.Arterial blood and peripheral venous blood were collected to examine the levels of blood lactic acid and UCP2 at admission.The patients were divided into death group and survival group according to the survival after 28 days of treatment.The correlation between UCP2 and blood lactate acid and the factors influencing the prognosis of cardiogenic shock were analyzed.The predictive value of blood lactate acid and UCP2 for the prognosis of cardiogenic shock was evaluated using receiver operating characteristic(ROC)curve.Results The levels of UCP2,blood lactic acid,troponin and bilirubin in the death group were significantly higher than those in the survival group(all P<0.05).Pearson analysis showed that UCP2 was positively correlated with blood lactate acid(r=0.529,P<0.05).Logistic analysis showed that the increase of UCP2,blood lactate,troponin and bilirubin were all risk factors for the prognosis of cardiogenic shock(all P<0.05).ROC curve showed that the AUC values of UCP2,blood lactate acid and their combination in predicting the prognosis of cardiogenic shock were 0.703,0.708 and 0.796,respectively.Conclusion UCP2 is positively correlated with blood lactate acid in the progression of cardiogenic shock.UCP2 and blood lactate acid have high predictive value for the prognosis of cardiogenic shock.
Cardiogenic shockUncoupling protein 2Blood lactic acidPrognosis
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NSTL
万方数据
