Efficacies of palonosetron,tropisetron and ondansetron in preventing vomiting after transcatheter arterial chemoembolization
Objective To compare the efficacies and adverse reactions of palonosetron hydrochloride with tropisetron and ondansetron in the prevention of nausea and vomiting after transcatheter arterial chemoembolization.Methods A total of 120 patients with postoperative liver metastasis of colorectal cancer who underwent transcatheter arterial chemoembolization were randomly divided into three groups.One hour before surgery,tropisetron hydrochloride(5 mg)was intravenously dripped in group A,ondansetron hydrochloride capsule(8 mg)was orally administered in group B,and palonosetron hydrochloride(0.25 mg)was intravenously injected in group C.No other antiemetics were used after surgery,and if necessary,intramuscular injection of metoclopramide(10 mg)was given for rescue.Results The complete response rates in preventing acute vomiting were 67.5%in group A,65.0%in group B,and 70.0%in group C,with no statistically significant difference(P>0.05).The complete response rate in preventing delayed vomiting was 87.5%in group C,which was significantly higher than those in group A(70.0%)and group B(60.0%)(P<0.05).The main adverse reactions in the three groups were mild constipation and abdominal distension.Conclusion Palonosetron,tropisetron,and ondansetron have satisfactory effects on preventing postoperative nausea and vomiting caused by transcatheter arterial chemoembolization,with mild and controllable adverse reactions.Palonosetron hydrochloride has a better effect on delayed vomiting.
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