Predictive value of the ratio of mean platelet volume to platelet count for prognosis of acute myocardial infarction patients with slow blood flow during interventional surgery
Objective To investigate the value of the ratio of mean platelet volume(MPV)to platelet count(PLT)in predicting slow flow and short-term prognosis in patients with acute myocardial infarction(AMI)undergoing interventional surgery.Methods A total of 100 patients with AMI who were admitted to General Hospital of Eastern Theater Command of PLA from November 2018 to September 2022 were selected as research objects.All the patients underwent percutaneous coronary intervention(PCI)after enrollment.According to the thrombolysis in myocardial infarction(TIMI)flow grade during the operation,the patients were divided into control group(TIMI grade 3,n=79)and slow flow group(TIMI grade 1-2,n=21).The patients were followed up for 30 days after discharge to collect the occurrence and time of major adverse cardiovascular event(MACE).The MPV/PLT value was compared between the two groups,and the effect and predictive value of MPV/PLT on the short-term prognosis of AMI patients were analyzed.Results MPV,MPV/PLT,CHA2DS2-VAsc score and sST-2 in the slow flow group were significantly higher than those in the control group(all P<0.05).The slow flow group had lower LVEF,shorter MACE-free survival time,and higher incidence of MACE than the control group(all P<0.05).Receiver operating characteristic(ROC)curve showed that MPV/PLT had higher value in predicting slow blood flow during PCI than PLT and MPV(both P<0.05),and the area under curve(AUC)was 0.91(95%CI:0.85-0.98).Binary logistic regression analysis showed that MPV/PLT was an independent risk factor for MACEs(OR=2.52,95%CI:1.38-5.07,P<0.01).Conclusion MPV/PLT is related to slow blood flow in AMI patients undergoing PCI.Dynamic monitoring of MPV/PLT can be used to predict the clinical prognosis of AMI patients.
Mean platelet volumePlatelet countAcute myocardial infarctionSlow blood flowShort-term prognosis
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