Correlation analysis of serum NF-κB,HMGB1 and Hsp70 with brain nerve injury and myocardial injury in children with febrile seizures
Objective To investigate the changes of serum nuclear factor κB(NF-κB),high mobility group box 1 protein(HMGB1)and heat shock protein 70(HSP70)in children with febrile seizures(FS),and to analyze their relationships with brain injury and myocardial injury.Methods Sixty FS children who were admitted to The Affiliated Hospital of Xuzhou Medical University from January 2020 to December 2021 were enrolled in this study.There were 37 children with simple febrile seizures(SFS)and 23 children with complex febrile seizures(CFS).In addition,30 febrile children without convulsion were selected as controls.The levels of NF-κB,MGB1,HSP70,serum brain-derived neurotrophic factor(BDNF),creatine kinase isoenzyme(CK-MB)and lactate dehydrogenase(LDH)were compared among the three groups.Pearson correlation analysis was used to analyze the relationships of NF-κB,MGB1 and HSP70 with BDNF,CK-MB and LDH.Results There were significant differences in BDNF,NF-κB,MGB1,HSP70,CK-MB and LDH among the three groups(all P<0.05).NF-κB was positively correlated with BDNF,CK-MB and LDH(all P<0.05).MGB1 was positively correlated with BDNF,CK-MB and LDH(all P<0.05).HSP70 was positively correlated with BDNF,CK-MB and LDH(all P<0.05).Conclusion The levels of NF-κB,MGB1 and HSP70 are significantly increased in children with FS,and were associated with brain nerve injury and myocardial injury.
Febrile seizuresNuclear factor κBHigh mobility group box 1 proteinHeat shock protein 70Correlation
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