Expression of ET-1 and PLGF in serum of preeclampsia patients in early pregnancy and its prognostic significance
Objective To investigate the expression of endothelin-1(ET-1)and placental growth factor(PLGF)in patients with preeclampsia in early pregnancy and its prognostic significance.Methods A total of 89 patients with preeclampsia who were admitted to No.904 Hospital of Joint Logistic Support Force of PLA from March 2019 to May 2021 were assigned to observation group.And 81 healthy pregnant women who underwent physical examination during the same period were enrolled as controls.Their clinical data were retrospectively analyzed.Serum ET-1 and PLGF levels were detected after admission.The correlation between serum ET-1 and PLGF levels was analyzed.All the participants were followed up until term pregnancy,and the prognoses of the two groups were compared.The patients in the observation group were subdivided into good prognosis group and poor prognosis group according to the prognoses.Multivariate logistic regression analysis was used to analyze the risk factors of poor prognosis in patients with preeclampsia.The receiver operating characteristic(ROC)curve was prepared,and the area under the curve(AUC)was used to evaluate the predictive value of serum ET-1 and PLGF levels for poor prognosis of preeclampsia patients.Results Serum ET-1 level in the observation group was higher than that in the control group,while serum PLGF level in the observation group was lower than that in the control group(both P<0.05).Pearson correlation analysis showed that there was a negative correlation between serum ET-1 and PLGF in both groups(P<0.05).The incidence of poor prognosis in the observation group was significantly higher than that in the control group(20.22%vs 7.41%,P<0.05).The proportion of severe cases,24-hour urine protein quantitation,uric acid,and serum ET-1 in the poor prognosis group were higher than those in the good prognosis group,while serum PLGF level in the poor prognosis group was lower than those in the good prognosis group(P<0.05).Multivariate logistic regression analysis showed that severe condition,24-hour urine protein quantitation,serum ET-1 and PLGF levels were risk factors for poor prognosis of preeclampsia patients(all P<0.05).The ROC curve showed that the AUC(95%CI)values of serum ET-1 and PLGF in predicting poor prognosis of preeclampsia were 0.825(0.709-0.906)and 0.771(0.651-0.852),respectively.Conclusion Patients with preeclampsia have higher ET-1 and lower PLGF than healthy pregnant women.Both ET-1 and PLGF can be used to predict the prognosis of patients with preeclampsia.
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